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Akihiro Tomoyasu
Researcher at Daiichi Sankyo
Publications - 22
Citations - 4364
Akihiro Tomoyasu is an academic researcher from Daiichi Sankyo. The author has contributed to research in topics: Nucleic acid & Peptide sequence. The author has an hindex of 6, co-authored 22 publications receiving 4221 citations. Previous affiliations of Akihiro Tomoyasu include Amgen & Saitama Medical University.
Papers
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Journal ArticleDOI
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
Hisataka Yasuda,Nobuyuki Shima,Nobuaki Nakagawa,Kyoji Yamaguchi,Masahiko Kinosaki,Shin Ichi Mochizuki,Akihiro Tomoyasu,Kazuki Yano,Masaaki Goto,Akihiko Murakami,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio,Nobuyuki Udagawa,Naoyuki Takahashi,Tatsuo Suda +15 more
TL;DR: In this article, a membrane-bound osteoclast differentiation factor (ODF) was found to induce OCL formation from osteoblasts/stromal cells in the presence of bone-resorbing factors.
Journal ArticleDOI
Characterization of monomeric and homodimeric forms of osteoclastogenesis inhibitory factor.
Akihiro Tomoyasu,Masaaki Goto,Nobuaki Fujise,Shinichi Mochizuki,Hisataka Yasuda,Tomonori Morinaga,Eisuke Tsuda,Kanji Higashio +7 more
TL;DR: Determination of the C-terminal amino-acid sequences of the two forms of r OCIF revealed that the monomeric rOCIF lacked several amino acids including Cys379, which is involved in the intermolecular disulfide bond, in its C-Terminal region.
Journal ArticleDOI
Purification and identification of a BMP-like factor from bovine serum
Kunihiko Kodaira,Mana Imada,Masaaki Goto,Akihiro Tomoyasu,Toru Fukuda,Ryutaro Kamijo,Tatsuo Suda,Kanji Higashio,Takenobu Katagiri +8 more
TL;DR: It is found that specific inhibitors of bone morphogenetic proteins (BMPs) stimulated myogenic differentiation even in the presence of 20% FBS, which in turn activated specific BMP signaling, indicating that BMP-like factor(s) in serum regulate both myogenic and osteoblastic differentiation.
Journal ArticleDOI
Platelet-rich plasma stimulates osteoblastic differentiation in the presence of BMPs
Akihiro Tomoyasu,Kanji Higashio,Kazuhiro Kanomata,Masaaki Goto,Masaaki Goto,Kunihiko Kodaira,Kunihiko Kodaira,Hiroko Serizawa,Tatsuo Suda,Atsushi Nakamura,Junya Nojima,Toru Fukuda,Takenobu Katagiri +12 more
TL;DR: Results suggested that platelets contain not only growth factors for proliferation but also novel potentiator(s) for BMP-dependent osteoblastic differentiation.
Patent
Antibodies to OCIF-binding molecules
Kyoji Yamaguchi,Hisataka Yasuda,Nobuaki Nakagawa,Nobuyuki Shima,Masahiko Kinosaki,Eisuke Tsuda,Masaaki Goto,Kazuki Yano,Akihiro Tomoyasu,Fumie Kobayashi,Naohiro Washida,Ken Takahashi,Tomonori Morinaga,Kanji Higashio +13 more
TL;DR: In this article, a novel protein which binds to Osteoclastogenesis Inhibitory Factor (OCIF-binding molecule; OBM), a process for preparing the same, DNA encoding said protein, a protein having an amino acid sequence encoded by this DNA, a method for producing said protein by genetic engineering technique, and a pharmaceutical composition containing said protein.