A
Akihiko Murakami
Publications - 11
Citations - 6540
Akihiko Murakami is an academic researcher. The author has contributed to research in topics: Erythropoietin & Osteoclast. The author has an hindex of 7, co-authored 10 publications receiving 6352 citations.
Papers
More filters
Journal ArticleDOI
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
Hisataka Yasuda,Nobuyuki Shima,Nobuaki Nakagawa,Kyoji Yamaguchi,Masahiko Kinosaki,Shin Ichi Mochizuki,Akihiro Tomoyasu,Kazuki Yano,Masaaki Goto,Akihiko Murakami,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio,Nobuyuki Udagawa,Naoyuki Takahashi,Tatsuo Suda +15 more
TL;DR: In this article, a membrane-bound osteoclast differentiation factor (ODF) was found to induce OCL formation from osteoblasts/stromal cells in the presence of bone-resorbing factors.
Journal ArticleDOI
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.
Hisataka Yasuda,Nobuyuki Shima,Nobuaki Nakagawa,Shinichi Mochizuki,Kazuki Yano,Nobuaki Fujise,Yasushi Sato,Masaaki Goto,Kyoji Yamaguchi,Masayoshi Kuriyama,Takeshi Kanno,Akihiko Murakami,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio +14 more
TL;DR: The cloning of a complementary DNA of human OCIF is reported, suggesting that the sites are involved in cell-to-cell signaling between stromal cells and osteoclast progenitors and that OPG/OCIF inhibits osteOClastogenesis by interrupting the signaling through the sites.
Journal ArticleDOI
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin.
Atsuko Mizuno,Norio Amizuka,Kazuharu Irie,Akihiko Murakami,Nobuaki Fujise,Takeshi Kanno,Yasushi Sato,Nobuaki Nakagawa,Hisataka Yasuda,Shinichi Mochizuki,Takashi Gomibuchi,Kazuki Yano,Nobuyuki Shima,Naohiro Washida,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio,Hidehiro Ozawa +17 more
TL;DR: It is demonstrated that the OCIF/OPG knockout mice provide the first animal model for osteoporosis without other obvious abnormalities and is a key factor acting as a negative regulator against osteoclastogenesis.
Journal ArticleDOI
Tumor cytotoxic factor/hepatocyte growth factor from human fibroblasts: cloning of its cDNA, purification and characterization of recombinant protein.
TL;DR: The deletion of five amino acids results in a conformational change which alters heparin binding and hepatocyte growth stimulating activities in F-TCF and the deleted form of recombinant F- TCF (rF-TCFs) was slightly lower inHeparin affinity than the intact form.
Journal ArticleDOI
Production of Recombinant Human Erythropoietin in Mammalian Cells: Host–Cell Dependency of the Biological Activity of the Cloned Glycoprotein
Masaaki Goto,Kunihisa Akai,Akihiko Murakami,Chika Hashimoto,Eisuke Tsuda,Masatsugu Ueda,Gosei Kawanishi,Noriko Takahashi,Akimine Ishimoto,Hideo Chiba,Ryuzo Sasaki +10 more
TL;DR: The results indicated that the carbohydrates attached to the EPO peptide are responsible for the different biological activities of these proteins.