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Shinichi Mochizuki
Researcher at University of Kitakyushu
Publications - 74
Citations - 4618
Shinichi Mochizuki is an academic researcher from University of Kitakyushu. The author has contributed to research in topics: Schizophyllan & DNA. The author has an hindex of 21, co-authored 74 publications receiving 4334 citations. Previous affiliations of Shinichi Mochizuki include Kyushu University.
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Journal ArticleDOI
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.
Hisataka Yasuda,Nobuyuki Shima,Nobuaki Nakagawa,Shinichi Mochizuki,Kazuki Yano,Nobuaki Fujise,Yasushi Sato,Masaaki Goto,Kyoji Yamaguchi,Masayoshi Kuriyama,Takeshi Kanno,Akihiko Murakami,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio +14 more
TL;DR: The cloning of a complementary DNA of human OCIF is reported, suggesting that the sites are involved in cell-to-cell signaling between stromal cells and osteoclast progenitors and that OPG/OCIF inhibits osteOClastogenesis by interrupting the signaling through the sites.
Journal ArticleDOI
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis
Eisuke Tsuda,Masaaki Goto,Shinichi Mochizuki,Kazuki Yano,Fumie Kobayashi,Tomonori Morinaga,Kanji Higashio +6 more
TL;DR: Data suggest that OCIF is a novel cytokine which specifically inhibits osteoclastogenesis, and has no homology to known proteins.
Journal ArticleDOI
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin.
Atsuko Mizuno,Norio Amizuka,Kazuharu Irie,Akihiko Murakami,Nobuaki Fujise,Takeshi Kanno,Yasushi Sato,Nobuaki Nakagawa,Hisataka Yasuda,Shinichi Mochizuki,Takashi Gomibuchi,Kazuki Yano,Nobuyuki Shima,Naohiro Washida,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio,Hidehiro Ozawa +17 more
TL;DR: It is demonstrated that the OCIF/OPG knockout mice provide the first animal model for osteoporosis without other obvious abnormalities and is a key factor acting as a negative regulator against osteoclastogenesis.
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Osteoclast Differentiation Factor Mediates an Essential Signal for Bone Resorption Induced by 1α,25-Dihydroxyvitamin D3, Prostaglandin E2, or Parathyroid Hormone in the Microenvironment of Bone
Katsuyoshi Tsukii,Nobuyuki Shima,Shinichi Mochizuki,Kyoji Yamaguchi,Masahiko Kinosaki,Kazuki Yano,Osamu Shibata,Nobuyuki Udagawa,Hiroshi Yasuda,Tatsuo Suda,Kanji Higashio +10 more
TL;DR: It is concluded that ODF plays a critical role in bone resorption in the microenvironment of bone and is significantly suppressed by anti-ODF polyclonal antibody and OPG/OCIF.
Journal ArticleDOI
Osteoclastogenesis inhibitory factor suppresses osteoclast survival by interfering in the interaction of stromal cells with osteoclast.
Takuhiko Akatsu,Takehiko Murakami,Miyuki Nishikawa,Katsuhiro Ono,Nariyoshi Shinomiya,Eisuke Tsuda,Shinichi Mochizuki,Kyoji Yamaguchi,Masahiko Kinosaki,Kanji Higashio,Michiko Yamamoto,Kazuo Motoyoshi,Naokazu Nagata +12 more
TL;DR: Osteoclastogenesis inhibitory factor inhibited not only OC recruitment but also OC survival by interfering the interaction of stromal cells with OC.