K
Kyoji Yamaguchi
Researcher at Daiichi Sankyo
Publications - 49
Citations - 8879
Kyoji Yamaguchi is an academic researcher from Daiichi Sankyo. The author has contributed to research in topics: Osteoclast & Peptide sequence. The author has an hindex of 14, co-authored 49 publications receiving 8598 citations. Previous affiliations of Kyoji Yamaguchi include Amgen.
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Journal ArticleDOI
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
Hisataka Yasuda,Nobuyuki Shima,Nobuaki Nakagawa,Kyoji Yamaguchi,Masahiko Kinosaki,Shin Ichi Mochizuki,Akihiro Tomoyasu,Kazuki Yano,Masaaki Goto,Akihiko Murakami,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio,Nobuyuki Udagawa,Naoyuki Takahashi,Tatsuo Suda +15 more
TL;DR: In this article, a membrane-bound osteoclast differentiation factor (ODF) was found to induce OCL formation from osteoblasts/stromal cells in the presence of bone-resorbing factors.
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Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.
Hisataka Yasuda,Nobuyuki Shima,Nobuaki Nakagawa,Shinichi Mochizuki,Kazuki Yano,Nobuaki Fujise,Yasushi Sato,Masaaki Goto,Kyoji Yamaguchi,Masayoshi Kuriyama,Takeshi Kanno,Akihiko Murakami,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio +14 more
TL;DR: The cloning of a complementary DNA of human OCIF is reported, suggesting that the sites are involved in cell-to-cell signaling between stromal cells and osteoclast progenitors and that OPG/OCIF inhibits osteOClastogenesis by interrupting the signaling through the sites.
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Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction
Kanichiro Kobayashi,Naoyuki Takahashi,Eijiro Jimi,Nobuyuki Udagawa,Masamichi Takami,Shigeru Kotake,Nobuaki Nakagawa,Masahiko Kinosaki,Kyoji Yamaguchi,Nobuyuki Shima,Hisataka Yasuda,Tomonori Morinaga,Kanji Higashio,T. John Martin,Tatsuo Suda +14 more
TL;DR: It is demonstrated that TNF-α stimulates osteoclast differentiation in the presence of M-CSF through a mechanism independent of the ODF/RANKL–RANK system.
Journal ArticleDOI
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis.
Nobuaki Nakagawa,Masahiko Kinosaki,Kyoji Yamaguchi,Nobuyuki Shima,Hisataka Yasuda,Kazuki Yano,Tomonori Morinaga,Kanji Higashio +7 more
TL;DR: Results indicate that RANK is the signaling receptor essential for ODF-mediated osteoclastogenesis, which is involved in the regulation of dendritic cell function.
Journal ArticleDOI
Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures.
Kenichiro Matsuzaki,Nobuyuki Udagawa,Naoyuki Takahashi,Kyoji Yamaguchi,Hisataka Yasuda,Nobuyuki Shima,Tomonori Morinaga,Yoshiaki Toyama,Yutaka Yabe,Kanji Higashio,Tatsuo Suda +10 more
TL;DR: The present study indicates that OCIF acts as a naturally occurring decoy receptor for ODF in inhibiting signal transduction in human osteoclast formation.