A
Akiko Masuda
Researcher at National Institute of Advanced Industrial Science and Technology
Publications - 29
Citations - 1222
Akiko Masuda is an academic researcher from National Institute of Advanced Industrial Science and Technology. The author has contributed to research in topics: Diffusion (business) & Fluorescence correlation spectroscopy. The author has an hindex of 17, co-authored 29 publications receiving 1080 citations.
Papers
More filters
Journal ArticleDOI
Structure and Activity of the RNA-Targeting Type III-B CRISPR-Cas Complex of Thermus thermophilus
Raymond H.J. Staals,Yoshihiro Agari,Saori Maki-Yonekura,Yifan Zhu,David W. Taylor,David W. Taylor,Esther van Duijn,Arjan Barendregt,Marnix Vlot,Jasper J. Koehorst,Keiko Sakamoto,Akiko Masuda,Naoshi Dohmae,Peter J. Schaap,Jennifer A. Doudna,Jennifer A. Doudna,Jennifer A. Doudna,Albert J. R. Heck,Koji Yonekura,John van der Oost,Akeo Shinkai +20 more
TL;DR: Electron microscopy revealed that the structure of TtCmr resembles a "sea worm" and is composed of a Cmr2-3 heterodimer "tail," a helical backbone of Cmr4 subunits capped by Cmr5 subunits, and a curled "head" containing Cmr1 and Cmr6.
Journal ArticleDOI
Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression
Masashi Takawa,Hyun-Soo Cho,Shinya Hayami,Gouji Toyokawa,Masaharu Kogure,Masaharu Kogure,Yuka Yamane,Yukiko Iwai,Kazuhiro Maejima,Koji Ueda,Akiko Masuda,Naoshi Dohmae,Helen I. Field,Tatsuhiko Tsunoda,Takaaki Kobayashi,Takayuki Akasu,Masanori Sugiyama,Shin Ichi Ohnuma,Yutaka Atomi,Bruce A.J. Ponder,Yusuke Nakamura,Yusuke Nakamura,Ryuji Hamamoto,Ryuji Hamamoto +23 more
TL;DR: It is shown that SETD8 regulates the function of proliferating cell nuclear antigen (PCNA) protein through lysine methylation, and an increase of methylated PCNA was found in cancer cells, and the expression levels ofSETD8 and PCNA were correlated in cancer tissue samples, suggesting that aberrant lysines methylation of PCNA may play a role in human carcinogenesis.
Journal ArticleDOI
Lysyl 5-Hydroxylation, a Novel Histone Modification, by Jumonji Domain Containing 6 (JMJD6)
Motoko Unoki,Akiko Masuda,Naoshi Dohmae,Kyohei Arita,Masanori Yoshimatsu,Yukiko Iwai,Yoshinori Fukui,Koji Ueda,Ryuji Hamamoto,Ryuji Hamamoto,Masahiro Shirakawa,Hiroyuki Sasaki,Yusuke Nakamura,Yusuke Nakamura +13 more
TL;DR: It is revealed that JMJD6 hydroxylates lysyl residues of histones H2A/H2B and H3/H4 in vivo by amino acid composition analysis, which indicates that histones are additional substrates ofJMJD6 in vivo.
Journal ArticleDOI
The Histone Methyltransferase SMYD2 Methylates PARP1 and Promotes Poly(ADP-ribosyl)ation Activity in Cancer Cells
Lianhua Piao,Daechun Kang,Takehiro Suzuki,Akiko Masuda,Naoshi Dohmae,Yusuke Nakamura,Ryuji Hamamoto,Ryuji Hamamoto +7 more
TL;DR: This study unveils a novel mechanism of PARP1 in human cancer through its methylation by SMYD2, which revealed enhanced poly(ADP-ribose) formation after oxidative stress, and positively regulated the poly(adinp-ribosyl)ation activity ofPARP1.
Journal ArticleDOI
New Fluorescence Correlation Spectroscopy Enabling Direct Observation of Spatiotemporal Dependence of Diffusion Constants as an Evidence of Anomalous Transport in Extracellular Matrices
TL;DR: This new method, namely, sampling-volume-controlled (SVC)-FCS, was applied to the analysis of hyaluronan aqueous solutions and indicates that moderate ASD may occur even in the presence of a small amount of HA in ECM.