A
Akira Kawaguchi
Researcher at National Institutes of Health
Publications - 15
Citations - 1083
Akira Kawaguchi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 10, co-authored 15 publications receiving 894 citations. Previous affiliations of Akira Kawaguchi include Tokyo University of Science & University of the Ryukyus.
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Journal ArticleDOI
Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo
Kenichi Niikura,Tatsuya Matsunaga,Tadaki Suzuki,Shintaro Kobayashi,Hiroki Yamaguchi,Yasuko Orba,Akira Kawaguchi,Hideki Hasegawa,Kiichi Kajino,Takafumi Ninomiya,Kuniharu Ijiro,Hirofumi Sawa +11 more
TL;DR: AuNPs are effective vaccine adjuvants and enhance the immune response via different cytokine pathways depending on their sizes and shapes, and the mechanisms of the shape-dependent WNVE antibody production are examined.
Journal ArticleDOI
Cross-Protection against H5N1 Influenza Virus Infection Is Afforded by Intranasal Inoculation with Seasonal Trivalent Inactivated Influenza Vaccine
Takeshi Ichinohe,Shin-ichi Tamura,Akira Kawaguchi,Akira Kawaguchi,Akira Kawaguchi,Ai Ninomiya,Masaki Imai,Shigeyuki Itamura,Takato Odagiri,Masato Tashiro,Hidehiro Takahashi,Hirofumi Sawa,William M. Mitchell,David R. Strayer,William A. Carter,Joe Chiba,Takeshi Kurata,Tetsutaro Sata,Hideki Hasegawa +18 more
TL;DR: Intranasal inoculation with annual influenza vaccine plus the Toll-like receptor—3 agonist, poly(I): poly(C12U) (Ampligen) as an adjuvant may overcome the problem of a limited supply of H5N1 virus vaccine by providing cross-protective mucosal immunity against H4N1 viruses with pandemic potential.
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Relationship of the quaternary structure of human secretory IgA to neutralization of influenza virus.
Tadaki Suzuki,Akira Kawaguchi,Akira Ainai,Shin-ichi Tamura,Ryo Ito,Pretty Multihartina,Vivi Setiawaty,Krisna Nur Andriana Pangesti,Takato Odagiri,Masato Tashiro,Hideki Hasegawa +10 more
TL;DR: The present study revealed, for the first time to the authors' knowledge, the existence of large polymeric IgA in the healthy human upper respiratory mucosa, as well as the physiological functions of these molecules in protecting against viral infection in humans.
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Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge.
Takeshi Ichinohe,Akira Kawaguchi,Akira Kawaguchi,Akira Kawaguchi,Shin-ichi Tamura,Hidehiro Takahashi,Hirofumi Sawa,Ai Ninomiya,Masaki Imai,Shigeyuki Itamura,Takato Odagiri,Masato Tashiro,Joe Chiba,Tetsutaro Sata,Takeshi Kurata,Hideki Hasegawa +15 more
TL;DR: It is shown that a new mucosal adjuvant, poly I:poly C12U (Ampligen), a Toll-like receptor 3 agonist proven to be safe in a Phase III human trial, is an effective adjUvant for H5N1 influenza vaccination.
Journal ArticleDOI
Inhibition of the SDF-1α–CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice
Akira Kawaguchi,Akira Kawaguchi,Yasuko Orba,Takashi Kimura,Hidekatsu Iha,Masao Ogata,Takahiro Tsuji,Akira Ainai,Tetsutaro Sata,Takashi Okamoto,William W. Hall,Hirofumi Sawa,Hideki Hasegawa +12 more
TL;DR: The involvement of the SDF-1alpha/CXCR4 interaction as one mechanism of leukemic cell migration and this may provide a novel target as part of combination therapy for ATL are demonstrated.