A
Alaa A.-M. Abdel-Aziz
Researcher at King Saud University
Publications - 152
Citations - 3931
Alaa A.-M. Abdel-Aziz is an academic researcher from King Saud University. The author has contributed to research in topics: Dihedral angle & Docking (molecular). The author has an hindex of 33, co-authored 144 publications receiving 3230 citations. Previous affiliations of Alaa A.-M. Abdel-Aziz include Mansoura University & University of Florence.
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Journal ArticleDOI
Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study
Adel S. El-Azab,Mohamed A. Al-Omar,Alaa A.-M. Abdel-Aziz,Naglaa I. Abdel-Aziz,Magda A.-A. El-Sayed,Abdulaziz M. Aleisa,Mohamed M. Sayed-Ahmed,Sami G. Abdel-Hamide +7 more
TL;DR: Novel derivatives of quinazoline have been synthesized and tested for their antitumor activity against three tumor cell lines among these cell lines the human breast carcinoma cell line (MCF-7) in which EGFR is highly expressed.
Journal ArticleDOI
Substituted quinazolines, part 3. Synthesis, in vitro antitumor activity and molecular modeling study of certain 2-thieno-4(3H)-quinazolinone analogs.
Abdulrahman M. Al-Obaid,Sami G. Abdel-Hamide,Hassan A. El-Kashef,Alaa A.-M. Abdel-Aziz,Adel S. El-Azab,Hamad A. Al-Khamees,Hussein I. El-Subbagh +6 more
TL;DR: Conformational analysis of the most active molecules using molecular modeling and QSAR techniques enabled the understanding of the pharmacophoric requirements for 2-thieno-quinzolinone derivatives as antitumor agents.
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Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs.
Sarah T. Al-Rashood,Ihsan A. Aboldahab,Mahmoud N. Nagi,Laila A. Abou-Zeid,Alaa A.-M. Abdel-Aziz,Sami G. Abdel-Hamide,Khairia M. Youssef,Abdulrahman M. Al-Obaid,Hussein I. El-Subbagh +8 more
TL;DR: A new series of quinazoline analogs was designed to resemble methotrexate (MTX, 1) structure features and fitted with functional groups believed to enhance inhibition of mammalian DHFR activity to produce potent new leads for anticancer drugs.
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Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.
Magda A.-A. El-Sayed,Naglaa I. Abdel-Aziz,Alaa A.-M. Abdel-Aziz,Alaa A.-M. Abdel-Aziz,Adel S. El-Azab,Adel S. El-Azab,Yousif A. Asiri,Kamal E.H. ElTahir +7 more
TL;DR: New arylhydrazone derivatives and a series of 1,5-diphenyl pyrazoles were designed and synthesized from 1-(4-chlorophenyl)-4,4, 4-trifuorobutane-1,3-dione and investigated in vivo for their anti-inflammatory activities and revealed a similar binding mode to SC-558, a selective COX-2 inhibitor.
Journal ArticleDOI
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.
Magda A.-A. El-Sayed,Naglaa I. Abdel-Aziz,Alaa A.-M. Abdel-Aziz,Alaa A.-M. Abdel-Aziz,Adel S. El-Azab,Adel S. El-Azab,Kamal E.H. ElTahir +6 more
TL;DR: New pyrazole and pyrazoline derivatives have been synthesized and their ability to inhibit ovine COX-1/COX-2 isozymes was evaluated using in vitro cyclooxygenase (COX) inhibition assay, and the anti-inflammatory activity of selected compounds was investigated in vivo using carrageenan-induced rat paw edema model.