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Adel S. El-Azab
Researcher at King Saud University
Publications - 142
Citations - 3221
Adel S. El-Azab is an academic researcher from King Saud University. The author has contributed to research in topics: Dihedral angle & Carbonic anhydrase. The author has an hindex of 29, co-authored 132 publications receiving 2585 citations. Previous affiliations of Adel S. El-Azab include Mansoura University & Cairo University.
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Journal ArticleDOI
Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study
Adel S. El-Azab,Mohamed A. Al-Omar,Alaa A.-M. Abdel-Aziz,Naglaa I. Abdel-Aziz,Magda A.-A. El-Sayed,Abdulaziz M. Aleisa,Mohamed M. Sayed-Ahmed,Sami G. Abdel-Hamide +7 more
TL;DR: Novel derivatives of quinazoline have been synthesized and tested for their antitumor activity against three tumor cell lines among these cell lines the human breast carcinoma cell line (MCF-7) in which EGFR is highly expressed.
Journal ArticleDOI
Substituted quinazolines, part 3. Synthesis, in vitro antitumor activity and molecular modeling study of certain 2-thieno-4(3H)-quinazolinone analogs.
Abdulrahman M. Al-Obaid,Sami G. Abdel-Hamide,Hassan A. El-Kashef,Alaa A.-M. Abdel-Aziz,Adel S. El-Azab,Hamad A. Al-Khamees,Hussein I. El-Subbagh +6 more
TL;DR: Conformational analysis of the most active molecules using molecular modeling and QSAR techniques enabled the understanding of the pharmacophoric requirements for 2-thieno-quinzolinone derivatives as antitumor agents.
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Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.
Magda A.-A. El-Sayed,Naglaa I. Abdel-Aziz,Alaa A.-M. Abdel-Aziz,Alaa A.-M. Abdel-Aziz,Adel S. El-Azab,Adel S. El-Azab,Yousif A. Asiri,Kamal E.H. ElTahir +7 more
TL;DR: New arylhydrazone derivatives and a series of 1,5-diphenyl pyrazoles were designed and synthesized from 1-(4-chlorophenyl)-4,4, 4-trifuorobutane-1,3-dione and investigated in vivo for their anti-inflammatory activities and revealed a similar binding mode to SC-558, a selective COX-2 inhibitor.
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Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.
Magda A.-A. El-Sayed,Naglaa I. Abdel-Aziz,Alaa A.-M. Abdel-Aziz,Alaa A.-M. Abdel-Aziz,Adel S. El-Azab,Adel S. El-Azab,Kamal E.H. ElTahir +6 more
TL;DR: New pyrazole and pyrazoline derivatives have been synthesized and their ability to inhibit ovine COX-1/COX-2 isozymes was evaluated using in vitro cyclooxygenase (COX) inhibition assay, and the anti-inflammatory activity of selected compounds was investigated in vivo using carrageenan-induced rat paw edema model.
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Non-classical antifolates. Part 2: Synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones
Fatmah A.M. Al-Omary,Laila A. Abou-Zeid,Mahmoud N. Nagi,El-Sayed E. Habib,Alaa A.-M. Abdel-Aziz,Adel S. El-Azab,Sami G. Abdel-Hamide,Mohamed A. Al-Omar,Abdulrahman M. Al-Obaid,Hussein I. El-Subbagh +9 more
TL;DR: A new series of 2,6-substituted-quinazolin-4-ones was designed, synthesized, and evaluated for their in vitro DHFR inhibition, antimicrobial, and antitumor activities and proved critical for biological activity.