A
Alan Colman
Researcher at University of Warwick
Publications - 80
Citations - 8855
Alan Colman is an academic researcher from University of Warwick. The author has contributed to research in topics: Embryonic stem cell & Xenopus. The author has an hindex of 39, co-authored 79 publications receiving 8569 citations. Previous affiliations of Alan Colman include University of Leicester.
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Cloned pigs produced by nuclear transfer from adult somatic cells
Irina A. Polejaeva,Shu-Hung Chen,Todd Vaught,Raymond L. Page,June Mullins,Suyapa Ball,Yifan Dai,Jeremy Boone,Shawn Walker,David Ayares,Alan Colman,Keith H.S. Campbell +11 more
TL;DR: The successful production of cloned piglets from a cultured adult somatic cell population using a new nuclear transfer procedure is reported and the methodology used for embryo reconstruction in each of these species is essentially similar.
Journal ArticleDOI
Targeted disruption of the α1,3-galactosyltransferase gene in cloned pigs
Yifan Dai,Todd Vaught,Jeremy Boone,Shu-Hung Chen,Carol Phelps,Suyapa Ball,Jeff A. Monahan,Peter M. Jobst,Kenneth J. McCreath,Ashley E. Lamborn,Jamie L. Cowell-Lucero,Kevin D. Wells,Alan Colman,Irina A. Polejaeva,David Ayares +14 more
TL;DR: The disruption of one allele of the pig α1,3GT gene in both male and female porcine primary fetal fibroblasts is reported, causing hyperacute rejection in pig-to-human xenotransplantation and producing cloned female piglets of normal weight and apparently healthy.
Journal ArticleDOI
Production of gene-targeted sheep by nuclear transfer from cultured somatic cells
Kenneth J. McCreath,J. Howcroft,Keith H.S. Campbell,Alan Colman,Angelika Schnieke,Alexander Kind +5 more
TL;DR: Efficient and reproducible gene targeting in fetal fibroblasts to place a therapeutic transgene at the ovine α1(I) procollagen (COL1A1) locus is described and the production of live sheep by nuclear transfer is described.
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Genomic alterations in cultured human embryonic stem cells
Anirban Maitra,Dan E. Arking,Narayan Shivapurkar,Morna Ikeda,Victor Stastny,Keyaunoosh Kassauei,Guoping Sui,David J. Cutler,Ying Liu,Sandii N. Brimble,Karin Noaksson,Johan Hyllner,Thomas C. Schulz,Xianmin Zeng,William J. Freed,Jeremy M. Crook,Suman Abraham,Alan Colman,Peter Sartipy,Sei Ichi Matsui,Melissa K. Carpenter,Adi F. Gazdar,Mahendra S. Rao,Aravinda Chakravarti +23 more
TL;DR: The observation that hESC lines maintained in vitro develop genetic and epigenetic alterations implies that periodic monitoring of these lines will be required before they are used in in vivo applications and that some late-passage hESS lines may be unusable for therapeutic purposes.
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High level expression of active human alpha-1-antitrypsin in the milk of transgenic sheep
TL;DR: Human α1AT purified from the milk of these animals appears to be fully N-glycosylated and has a biological activity indistinguishable from human plasma-derived material.