M
Morna Ikeda
Researcher at Johns Hopkins University School of Medicine
Publications - 5
Citations - 1952
Morna Ikeda is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Genetic association & Population. The author has an hindex of 5, co-authored 5 publications receiving 1890 citations. Previous affiliations of Morna Ikeda include Johns Hopkins University.
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Journal ArticleDOI
Genomic alterations in cultured human embryonic stem cells
Anirban Maitra,Dan E. Arking,Narayan Shivapurkar,Morna Ikeda,Victor Stastny,Keyaunoosh Kassauei,Guoping Sui,David J. Cutler,Ying Liu,Sandii N. Brimble,Karin Noaksson,Johan Hyllner,Thomas C. Schulz,Xianmin Zeng,William J. Freed,Jeremy M. Crook,Suman Abraham,Alan Colman,Peter Sartipy,Sei Ichi Matsui,Melissa K. Carpenter,Adi F. Gazdar,Mahendra S. Rao,Aravinda Chakravarti +23 more
TL;DR: The observation that hESC lines maintained in vitro develop genetic and epigenetic alterations implies that periodic monitoring of these lines will be required before they are used in in vivo applications and that some late-passage hESS lines may be unusable for therapeutic purposes.
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A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism.
Dan E. Arking,David J. Cutler,Camille W. Brune,Tanya M. Teslovich,Kristen West,Morna Ikeda,Alexis Rea,Moltu Guy,Shin Lin,Edwin H. Cook,Aravinda Chakravarti +10 more
TL;DR: A common polymorphism in contactin-associated protein-like 2 (CNTNAP2), a member of the neurexin superfamily, that is significantly associated with autism susceptibility is identified and displays a parent-of-origin and gender effect recapitulating the inheritance of autism.
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A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.
Dan E. Arking,Arne Pfeufer,Wendy S. Post,Wendy S. Post,W. H. Linda Kao,Christopher Newton-Cheh,Christopher Newton-Cheh,Morna Ikeda,Kristen West,Carl S. Kashuk,Mahmut Akyol,Siegfried Perz,Shapour Jalilzadeh,Thomas Illig,Christian Gieger,Chao-Yu Guo,Martin G. Larson,H.-Erich Wichmann,Eduardo Marbán,Christopher J. O'Donnell,Christopher J. O'Donnell,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Stefan Kääb,Peter M. Spooner,Thomas Meitinger,Aravinda Chakravarti +27 more
TL;DR: This genome-wide study identified NOS1AP (CAPON), a regulator of neuronal nitric oxide synthase, as a new target that modulates cardiac repolarization, which explains up to 1.5% of QT interval variation.
Journal ArticleDOI
Multiple Genes for Essential-Hypertension Susceptibility on Chromosome 1q
Yen Pei C. Chang,Xin Liu,James Kim,Morna Ikeda,Marnie R. Layton,Alan B. Weder,Richard S. Cooper,Sharon L.R. Kardia,D. C. Rao,Steve C. Hunt,Amy Luke,Eric Boerwinkle,Aravinda Chakravarti +12 more
TL;DR: It is demonstrated that a replicated linkage peak for BP regulation on human chromosome 1q, homologous to mouse and rat quantitative trait loci for BP, contains at least three genes associated with BP levels in multiple samples: ATP1B1, RGS5, and SELE.
Journal ArticleDOI
Linkage Disequilibrium and Haplotype Diversity in the Genes of the Renin–Angiotensin System: Findings From the Family Blood Pressure Program
Xiaofeng Zhu,Denise Yan,Richard S. Cooper,Amy Luke,Morna Ikeda,Yen Pei C. Chang,Alan B. Weder,Aravinda Chakravarti +7 more
TL;DR: There was less LD among blacks, the number of haplotypes was substantially larger, and shorter haplotype segments were found, compared with whites, which indicates that variation between populations of European and African origin in haplotype diversity is characteristic of most genes.