N
Narayan Shivapurkar
Researcher at University of Texas Southwestern Medical Center
Publications - 51
Citations - 4328
Narayan Shivapurkar is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 38, co-authored 51 publications receiving 4224 citations. Previous affiliations of Narayan Shivapurkar include University of Texas at Dallas.
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Journal ArticleDOI
Genomic alterations in cultured human embryonic stem cells
Anirban Maitra,Dan E. Arking,Narayan Shivapurkar,Morna Ikeda,Victor Stastny,Keyaunoosh Kassauei,Guoping Sui,David J. Cutler,Ying Liu,Sandii N. Brimble,Karin Noaksson,Johan Hyllner,Thomas C. Schulz,Xianmin Zeng,William J. Freed,Jeremy M. Crook,Suman Abraham,Alan Colman,Peter Sartipy,Sei Ichi Matsui,Melissa K. Carpenter,Adi F. Gazdar,Mahendra S. Rao,Aravinda Chakravarti +23 more
TL;DR: The observation that hESC lines maintained in vitro develop genetic and epigenetic alterations implies that periodic monitoring of these lines will be required before they are used in in vivo applications and that some late-passage hESS lines may be unusable for therapeutic purposes.
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A Genome-Wide Screen for Promoter Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies
David S. Shames,Luc Girard,Boning Gao,Mitsuo Sato,Cheryl M. Lewis,Narayan Shivapurkar,Aixiang Jiang,Charles M. Perou,Young Ho Kim,Jonathan R. Pollack,Kwun M. Fong,Chi Leung Lam,Maria Wong,Yu Shyr,Rita Nanda,Olufunmilayo I. Olopade,William L. Gerald,David M. Euhus,Jerry W. Shay,Adi F. Gazdar,John D. Minna +20 more
TL;DR: The data suggest that while tumors in different tissues vary substantially with respect to gene expression, there may be commonalities in their promoter methylation profiles that represent targets for early detection screening or therapeutic intervention.
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Apoptosis and lung cancer: A review
TL;DR: The role of apoptosis regulation in lung cancer with major focus on the differential sensitivities of the major subtypes is reviewed and should enable a more rational approach to anticancer drug design and therapy.
Journal Article
Deregulation of Caspase 8 and 10 Expression in Pediatric Tumors and Cell Lines
Kenichi Harada,Shinichi Toyooka,Narayan Shivapurkar,Anirban Maitra,Jyotsna Reddy,Hittu Matta,Kuniharu Miyajima,Charles F. Timmons,Gail E. Tomlinson,Domenico Mastrangelo,Robert J. Hay,Preet M. Chaudhary,Adi F. Gazdar +12 more
TL;DR: Deregulation of the death receptor pathway to apoptosis is frequent in many types of pediatric tumors and their cell lines and exposure to a demethylating agent is suggested.
Journal ArticleDOI
Differential inactivation of caspase-8 in lung cancers
Narayan Shivapurkar,Shinichi Toyooka,Michael T. Eby,Chun Xian Huang,Ubaradka G. Sathyanarayana,H. Thomas Cunningham,Jyotsna Reddy,Elizabeth Brambilla,Takashi Takahashi,John D. Minna,Preet M. Chaudhary,Adi F. Gazdar +11 more
TL;DR: Caspase-8 expression is absent in a subset of both high grade (SCLC) and low grade (carcinoid) neuroendocrine lung tumors but not in NSCLC, which usually lack neuro endocrine features.