A
Alan Gerber
Researcher at Rockefeller University
Publications - 14
Citations - 828
Alan Gerber is an academic researcher from Rockefeller University. The author has contributed to research in topics: Suprachiasmatic nucleus & Transcription (biology). The author has an hindex of 8, co-authored 14 publications receiving 618 citations. Previous affiliations of Alan Gerber include VU University Amsterdam & University of Geneva.
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Journal ArticleDOI
Clock-Talk: Interactions between central and peripheral circadian oscillators in mammals
Ueli Schibler,Ivana Gotic,Camille Saini,Pascal Gos,Thomas Curie,Yann Emmenegger,Flore Sinturel,Pauline Gosselin,Alan Gerber,Fabienne Fleury-Olela,Gianpaolo Rando,Maud Demarque,Paul Franken +12 more
TL;DR: In mice and rats, feeding-fasting rhythms, which are driven by the SCN through rest-activity cycles, are the most potent Zeitgebers for the circadian oscillators of peripheral organs.
Journal ArticleDOI
Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles.
Flore Sinturel,Alan Gerber,Daniel Mauvoisin,Daniel Mauvoisin,Jingkui Wang,Jingkui Wang,David Gatfield,Jeremy J. Stubblefield,Carla B. Green,Frédéric Gachon,Frédéric Gachon,Ueli Schibler +11 more
TL;DR: In mice, liver mass, hepatocyte size, and protein levels follow a daily rhythm, whose amplitude depends on both feeding-fasting and light-dark cycles, and it is proposed that rRNAs not packaged into complete ribosomal subunits are polyadenylated by the poly(A) polymerase PAPD5 and degraded by the nuclear exosome.
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Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity
TL;DR: The data suggest that in mouse liver SRF is regulated via dramatic diurnal changes of actin dynamics, leading to the rhythmic translocation of the SRF coactivator Myocardin-related transcription factor-B (MRTF-B) into the nucleus.
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The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPARα-Dependent Mechanisms
Jerome N. Feige,Alan Gerber,Cristina Casals-Casas,Qian Yang,Carine Winkler,Elodie Bedu,Manuel Bueno,Laurent Gelman,Johan Auwerx,Frank J. Gonzalez,Béatrice Desvergne +10 more
TL;DR: It is demonstrated that DEHP exerts species-specific metabolic actions that rely to a large extent on PPARα signaling and highlight the metabolic importance of the species- specific activation of PPAR α by xenobiotic compounds.
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The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion
TL;DR: It is proved that Necl-3/SynCAM-2 is a bona fide adhesion molecule that engages in homo- and heterophilic interactions with the other Necl family members, leading to cell aggregation.