Alan R. Cohen

TL;DR: Prophylaxis with recombinant factor VIII can prevent joint damage and decrease the frequency of joint and other hemorrhages in young boys with severe hemophilia A.

TL;DR: This review identified the need for additional studies in many key areas of the therapy of ITP such as comparative studies of "front-line" therapy for ITP, the management of serious bleeding in patients withITP, and studies that will provide guidance about which therapy should be used as salvage therapy for patients after failure of a first-line intervention.

TL;DR: Univariate analysis demonstrated that factors affecting cardiac disease-free survival were age at the start of chelation therapy and life-table analysis to estimate freedom from cardiac disease over time.

TL;DR: It is shown that a null mutation in motif D of the reverse transcriptase domain of the protein component of telomerase, hTERT, is associated with this phenotype and emphasizes the importance of telomere maintenance and telomer enzyme dosage for maintaining tissue proliferative capacity and has relevance for understanding mechanisms of age-related changes.

TL;DR: It is concluded that hepatitis C, iron-related organ dysfunction, and complications of iron chelation therapy are strongly age-dependent in North American patients with beta-thalassemia.