A
Alan Wainman
Researcher at University of Oxford
Publications - 38
Citations - 1856
Alan Wainman is an academic researcher from University of Oxford. The author has contributed to research in topics: Centrosome & Centriole. The author has an hindex of 20, co-authored 33 publications receiving 1506 citations. Previous affiliations of Alan Wainman include Sapienza University of Rome.
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Journal ArticleDOI
Centrosome function and assembly in animal cells
TL;DR: Advances should ultimately allow the in vitro reconstitution of functional centrosomes from their component proteins to unlock the secrets of these enigmatic organelles.
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The Centrosome-Specific Phosphorylation of Cnn by Polo/Plk1 Drives Cnn Scaffold Assembly and Centrosome Maturation
Paul T. Conduit,Zhe Feng,Jennifer H. Richens,Janina Baumbach,Alan Wainman,Suruchi D. Bakshi,Jeroen Dobbelaere,Steven Johnson,Susan M. Lea,Jordan W. Raff +9 more
TL;DR: It is concluded that Polo/Plk1 initiates the phosphorylation-dependent assembly of a Cnn scaffold around centrioles that is essential for efficient centrosome maturation in flies.
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Imaging cellular structures in super-resolution with SIM, STED and Localisation Microscopy: A practical comparison.
Eva Wegel,Antonia Gohler,B C Lagerholm,Alan Wainman,Stephan Uphoff,Rainer Kaufmann,Rainer Kaufmann,Ian M. Dobbie +7 more
TL;DR: In this article, the authors compare the individual strengths and weaknesses of SIM, STED, and SMLM by imaging a variety of different subcellular structures in fixed cells.
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A molecular mechanism of mitotic centrosome assembly in Drosophila
Paul T. Conduit,Jennifer H. Richens,Alan Wainman,James Holder,Catarina Vicente,Metta B. Pratt,Carly I Dix,Zsofia A Novak,Ian M. Dobbie,Lothar Schermelleh,Jordan W. Raff +10 more
TL;DR: This study shows that the centriole protein Asl initiates the recruitment of DSpd-2 and Cnn to mother centrioles; both proteins then assemble into co-dependent scaffold-like structures that spread outwards from the mother centRIole and recruit most, if not all, other PCM components.
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A Microtubule Interactome: Complexes with Roles in Cell Cycle and Mitosis
Julian R. Hughes,Ana M. Meireles,Ana M. Meireles,Katherine H. Fisher,Ángel García,Philip R Antrobus,Alan Wainman,Nicole Zitzmann,Charlotte M. Deane,Hiroyuki Ohkura,James G. Wakefield +10 more
TL;DR: This study uses a MT cosedimentation assay, combined with 1D and 2D PAGE and mass spectrometry, to identify over 250 MAPs from early Drosophila embryos and identifies new MAPs, many of which appear to be important in cell division.