A
Albert H. van Gennip
Researcher at University of Amsterdam
Publications - 52
Citations - 5186
Albert H. van Gennip is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Dihydropyrimidine dehydrogenase & Dihydropyrimidine dehydrogenase deficiency. The author has an hindex of 25, co-authored 51 publications receiving 4885 citations. Previous affiliations of Albert H. van Gennip include Maastricht University.
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Journal ArticleDOI
Histone deacetylases (HDACs): characterization of the classical HDAC family
Annemieke J.M. de Ruijter,Albert H. van Gennip,Huib N. Caron,Stephan Kemp,André B.P. van Kuilenburg +4 more
TL;DR: In this paper, a comprehensive overview of the structure, function and tissue distribution of members of the classical histone deacetylase (HDAC) family, in order to gain insight into the regulation of gene expression through HDAC activity is presented.
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Increased risk of grade IV neutropenia after administration of 5‐fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: High prevalence of the IVS14+1g>a mutation
TL;DR: Screening of patients at risk before administration of 5‐FU‐related toxicities in patients with low DPD activity and the apparently high prevalence of the IVS14+1G>A mutation is warranted.
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High prevalence of the IVS14+1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity
TL;DR: In this article, the authors evaluated the DPD activity and the prevalence of the common splice site mutation IVS14 + 1G>A in tumour patients suffering from severe grade 3-4 toxicity after the administration of 5FU.
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L-2-hydroxyglutaric acidemia: a novel inherited neurometabolic disease.
Peter G. Barth,Georg F. Hoffmann,Jaak Jaeken,Willy Lehnert,Folker Hanefeld,Albert H. van Gennip,Marinus Duran,Jaap Valk,Ruud B.H. Schutgens,Friedrich K. Trefz,Gabriele Reimann,Hans-Peter Hartung +11 more
TL;DR: A novel inherited neurometabolic disease, probably autosomal recessive, with distinct clinical, biochemical, and neuroimaging features is described, and the elevated CSF/plasma ratio suggests that it is in part generated within the central nervous system.
Journal ArticleDOI
Analysis of very long-chain fatty acids using electrospray ionization mass spectrometry.
Fredoen Valianpour,Jacqueline J.M Selhorst,Lia E.M van Lint,Albert H. van Gennip,Ronald J.A. Wanders,Stephan Kemp +5 more
TL;DR: A rapid and easy method using electrospray ionization mass spectrometry (ESI-MS) with deuterated internal standards to determine elevated levels of very long-chain fatty acids in plasma and fibroblasts of patients with X-ALD.