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Alberto Diaspro
Researcher at Istituto Italiano di Tecnologia
Publications - 662
Citations - 15768
Alberto Diaspro is an academic researcher from Istituto Italiano di Tecnologia. The author has contributed to research in topics: Microscopy & STED microscopy. The author has an hindex of 56, co-authored 608 publications receiving 13786 citations. Previous affiliations of Alberto Diaspro include European Institute of Oncology & University of Milano-Bicocca.
Papers
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Journal ArticleDOI
Precisely and accurately localizing single emitters in fluorescence microscopy
Hendrik Deschout,Francesca Cella Zanacchi,Michael J. Mlodzianoski,Alberto Diaspro,Joerg Bewersdorf,Samuel T. Hess,Kevin Braeckmans +6 more
TL;DR: A lucid synthesis of the developments on single-molecule localization precision and accuracy and their practical implications are presented in order to guide the increasing number of researchers using single-particle tracking and super-resolution localization microscopy.
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Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration.
Andrea Palamidessi,Emanuela Frittoli,Massimiliano Garrè,Mario Faretta,Marina Mione,Ilaria Testa,Alberto Diaspro,Letizia Lanzetti,Giorgio Scita,Pier Paolo Di Fiore +9 more
TL;DR: It is demonstrated that a Rab5-to-Rac circuitry controls the morphology of motile mammalian tumor cells and primordial germinal cells during zebrafish development, suggesting that this circuitry is relevant for the regulation of migratory programs in various cells, in both in vitro settings and whole organisms.
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STED super-resolved microscopy.
TL;DR: The future of this method in regard to spatiotemporal limits, live-cell imaging and combination with spectroscopy is discussed, and advances in these areas may elevate STED microscopy to a standard method for imaging in the life sciences.
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Live-cell 3D super-resolution imaging in thick biological samples
Francesca Cella Zanacchi,Zeno Lavagnino,Zeno Lavagnino,Michela Perrone Donnorso,Alessio Del Bue,Laura Furia,Mario Faretta,Alberto Diaspro,Alberto Diaspro +8 more
TL;DR: 3D super-resolution imaging of cellular spheroids is demonstrated by coupling far-field individual molecule localization with selective plane illumination microscopy (SPIM), which allows nanometric localization of single molecules in thick scattering specimens without activating or exciting molecules outside the focal plane.
Journal Article
Aloe-emodin Is a New Type of Anticancer Agent with Selective Activity against Neuroectodermal Tumors
Teresa Pecere,M. V. Gazzola,C. Mucignat,Cristina Parolin,Francesca Dalla Vecchia,Andrea Cavaggioni,Giuseppe Basso,Alberto Diaspro,B. Salvato,Modesto Carli,Giorgio Palù +10 more
TL;DR: Aloe-emodin (AE), a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antineuroectodermal tumor activity and might represent a conceptually new lead antitumor drug.