K
Kevin Braeckmans
Researcher at Ghent University
Publications - 290
Citations - 15698
Kevin Braeckmans is an academic researcher from Ghent University. The author has contributed to research in topics: Drug delivery & Chemistry. The author has an hindex of 62, co-authored 263 publications receiving 12832 citations. Previous affiliations of Kevin Braeckmans include Ludwig Maximilian University of Munich & university of lille.
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Journal ArticleDOI
The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls
Dries Vercauteren,Roosmarijn E. Vandenbroucke,Arwyn Tomos Jones,Joanna Rejman,Joseph Demeester,Stefaan C. De Smedt,Niek N. Sanders,Kevin Braeckmans +7 more
TL;DR: It is found that chlorpromazine and to a lesser extent MbetaCD significantly decreased cell viability of some cell lines even after short incubation periods and at concentrations that are routinely used to inhibit endocytosis.
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Cellular toxicity of inorganic nanoparticles: Common aspects and guidelines for improved nanotoxicity evaluation
Stefaan J. Soenen,Pilar Rivera-Gil,Jose-Maria Montenegro,Wolfgang J. Parak,Stefaan C. De Smedt,Kevin Braeckmans +5 more
TL;DR: An overview of the cytotoxic effects of commonly used inorganic NPs: quantum dots, gold and iron oxide nanoparticles is presented and suggestions are made on how to optimize NP design in view of minimal cytotoxicity.
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Polymer-Coated Nanoparticles Interacting with Proteins and Cells: Focusing on the Sign of the Net Charge
Dominik Hühn,Karsten Kantner,Christian Geidel,Stefan Brandholt,Ine De Cock,Stefaan J. Soenen,Pilar Rivera Gil,Jose-Maria Montenegro,Kevin Braeckmans,Klaus Müllen,G. Ulrich Nienhaus,G. Ulrich Nienhaus,Markus Klapper,Wolfgang J. Parak +13 more
TL;DR: This study shows that the number of adsorbed human serum albumin molecules per NP was not influenced by their surface charge, and cytot toxicity assays revealed a higher cytotoxicity for positively charged NPs, associated with their enhanced uptake.
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Precisely and accurately localizing single emitters in fluorescence microscopy
Hendrik Deschout,Francesca Cella Zanacchi,Michael J. Mlodzianoski,Alberto Diaspro,Joerg Bewersdorf,Samuel T. Hess,Kevin Braeckmans +6 more
TL;DR: A lucid synthesis of the developments on single-molecule localization precision and accuracy and their practical implications are presented in order to guide the increasing number of researchers using single-particle tracking and super-resolution localization microscopy.
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Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles.
Sander A.A. Kooijmans,Stephan Stremersch,Kevin Braeckmans,Stefaan C. De Smedt,An Hendrix,Matthew J.A. Wood,Raymond M. Schiffelers,Koen Raemdonck,Pieter Vader,Pieter Vader +9 more
TL;DR: The results show that electroporation of EVs with siRNA is accompanied by extensive siRNA aggregate formation, which may cause overestimation of the amount of siRNA actually loaded into EVs, and highlight the necessity for alternative methods to prepare siRNA-loaded EVs.