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Alberto Elosegui-Artola
Researcher at Harvard University
Publications - 30
Citations - 4315
Alberto Elosegui-Artola is an academic researcher from Harvard University. The author has contributed to research in topics: Extracellular matrix & Actin cytoskeleton. The author has an hindex of 16, co-authored 30 publications receiving 3023 citations. Previous affiliations of Alberto Elosegui-Artola include Wyss Institute for Biologically Inspired Engineering & University of Barcelona.
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Journal ArticleDOI
Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores
Alberto Elosegui-Artola,Ion Andreu,Ion Andreu,Amy E. M. Beedle,Amy E. M. Beedle,Ainhoa Lezamiz,Ainhoa Lezamiz,Marina Uroz,Anita Joanna Kosmalska,Roger Oria,Jenny Z. Kechagia,Palma Rico-Lastres,Palma Rico-Lastres,Anabel-Lise Le Roux,Catherine M. Shanahan,Xavier Trepat,Daniel Navajas,Sergi Garcia-Manyes,Sergi Garcia-Manyes,Pere Roca-Cusachs +19 more
TL;DR: This work shows that force applied to the nucleus directly drives YAP nuclear translocation by decreasing the mechanical restriction of nuclear pores to molecular transport, demonstrated for YAP but with potential general applicability in transcriptional regulation.
Journal ArticleDOI
Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity
Alberto Elosegui-Artola,Roger Oria,Yunfeng Chen,Yunfeng Chen,Anita Joanna Kosmalska,Carlos Pérez-González,Natalia Castro,Cheng Zhu,Cheng Zhu,Xavier Trepat,Pere Roca-Cusachs +10 more
TL;DR: It is shown that in response to matrix rigidity and density, force transmission and transduction are explained by the mechanical properties of the actin–talin–integrin–fibronectin clutch.
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A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion
Anna Labernadie,Takuya Kato,Agustí Brugués,Xavier Serra-Picamal,Stefanie Derzsi,Esther N. Arwert,Anne Weston,Víctor González-Tarragó,Alberto Elosegui-Artola,Lorenzo Albertazzi,Jordi Alcaraz,Pere Roca-Cusachs,Erik Sahai,Xavier Trepat +13 more
TL;DR: The findings show that a mechanically active heterophilic adhesion between CAFs and cancer cells enables cooperative tumour invasion.
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Collective cell durotaxis emerges from long-range intercellular force transmission.
Raimon Sunyer,Vito Conte,Jorge Escribano,Alberto Elosegui-Artola,Anna Labernadie,Léo Valon,Daniel Navajas,José Manuel García-Aznar,José J. Muñoz,Pere Roca-Cusachs,Xavier Trepat +10 more
TL;DR: Collective durotaxis emerges as a robust mechanism to direct cell migration during development, wound healing, and collective cancer cell invasion.
Journal ArticleDOI
Control of cell–cell forces and collective cell dynamics by the intercellular adhesome
Elsa Bazellières,Vito Conte,Alberto Elosegui-Artola,Xavier Serra-Picamal,María Bintanel-Morcillo,Pere Roca-Cusachs,José J. Muñoz,Marta Sales-Pardo,Roger Guimerà,Xavier Trepat +9 more
TL;DR: This work shows that collective cellular responses to selective perturbations of the intercellular adhesome conform to three mechanical phenotypes; these phenotypes are controlled by different molecular modules and characterized by distinct relationships between cellular kinematics and inter cellular forces.