Pere Roca-Cusachs

TL;DR: It is shown that mechanical stretching of single cytoplasmic proteins can activate binding of other molecules and molecular mechanotransduction can occur by protein binding after exposure of buried binding sites in the talin-vinculin system.

TL;DR: This work shows that force applied to the nucleus directly drives YAP nuclear translocation by decreasing the mechanical restriction of nuclear pores to molecular transport, demonstrated for YAP but with potential general applicability in transcriptional regulation.

TL;DR: An overview of how integrin function is regulated from both a biochemical and a mechanical perspective, affecting integrin cell-surface availability, binding properties, activation or clustering is provided, and how this biomechanical regulation allows integrins to respond to different ECM physicochemical properties and signals.

TL;DR: It is shown that in response to matrix rigidity and density, force transmission and transduction are explained by the mechanical properties of the actin–talin–integrin–fibronectin clutch.

TL;DR: The findings show that a mechanically active heterophilic adhesion between CAFs and cancer cells enables cooperative tumour invasion.