M
Miguel Vidal
Researcher at Spanish National Research Council
Publications - 84
Citations - 12557
Miguel Vidal is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Gene & Cellular differentiation. The author has an hindex of 43, co-authored 82 publications receiving 11787 citations. Previous affiliations of Miguel Vidal include Heidelberg University & National Institute for Medical Research.
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Journal ArticleDOI
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Laurie A. Boyer,Kathrin Plath,Kathrin Plath,Julia Zeitlinger,Tobias Brambrink,Lea Ann Medeiros,Tong Ihn Lee,Stuart S. Levine,Marius Wernig,Adriana Tajonar,Mridula K. Ray,George W. Bell,Arie P. Otte,Miguel Vidal,David K. Gifford,Richard A. Young,Rudolf Jaenisch +16 more
TL;DR: It is shown that PcG proteins directly repress a large cohort of developmental regulators in murine ES cells, the expression of which would otherwise promote differentiation, and dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development.
Journal ArticleDOI
Role of histone H2A ubiquitination in Polycomb silencing
Hengbin Wang,Liangjun Wang,Hediye Erdjument-Bromage,Miguel Vidal,Paul Tempst,Richard S. Jones,Yi Zhang +6 more
TL;DR: The purification and functional characterization of an E3 ubiquitin ligase complex that is specific for histone H2A is reported, and it is linked to Polycomb silencing, which is important in regulating chromatin dynamics and transcription.
Journal ArticleDOI
Polycomb Group Proteins Ring1A/B Link Ubiquitylation of Histone H2A to Heritable Gene Silencing and X Inactivation
Mariana de Napoles,Jacqueline E. Mermoud,Rika Wakao,Y. Amy Tang,Mitusuhiro Endoh,Ruth Appanah,Tatyana B. Nesterova,José C. R. Silva,Arie P. Otte,Miguel Vidal,Haruhiko Koseki,Neil Brockdorff +11 more
TL;DR: It is demonstrated that uH2A occurs on the inactive X chromosome in female mammals and that this correlates with recruitment of Polycomb group (PcG) proteins belonging to Polycomb repressor complex 1 (PRC1).
Journal ArticleDOI
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
Julie K. Stock,Sara Giadrossi,Miguel Casanova,Emily Brookes,Miguel Vidal,Haruhiko Koseki,Neil Brockdorff,Amanda G. Fisher,Ana Pombo +8 more
TL;DR: It is shown here that this important subset of developmental regulator genes, termed bivalent genes, assemble RNAP complexes phosphorylated on Ser 5 and are transcribed at low levels, providing an insight into the molecular mechanisms that allow ES cells to self-renew and yet retain the ability to generate multiple lineage outcomes.
Journal ArticleDOI
RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3
Lígia Tavares,Emilia Dimitrova,David Oxley,Judith Webster,Raymond A. Poot,Jeroen Demmers,Karel Bezstarosti,Stephen Taylor,Hiroki Ura,Hiroshi Koide,Anton Wutz,Miguel Vidal,Sarah Elderkin,Neil Brockdorff +13 more
TL;DR: It is shown that RING1B, the catalytic subunit of PRC1, and associated monoubiquitylation of histone H2A are targeted to closely overlapping sites in wild-type and PRC2-deficient mouse embryonic stem cells (mESCs), demonstrating an H3K27me3-independent pathway for recruitment ofPRC1 activity.