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Alejandro A. Schäffer

Researcher at National Institutes of Health

Publications -  269
Citations -  98821

Alejandro A. Schäffer is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 74, co-authored 249 publications receiving 92583 citations. Previous affiliations of Alejandro A. Schäffer include Rice University & Bell Labs.

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Repurposing CAR targets in solid tumors via a pan-cancer single-cell transcriptome analysis

TL;DR: In this paper, the authors mined single cell transcriptomics datasets of solid tumors and surveyed many existing CAR targets, aiming to new solid tumor types in which these targets are differentially expressed in tumor cells and not on non-tumor cells within the tumor microenvironment, thus providing new repurposing opportunities.
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A deep learning approach reveals unexplored landscape of viral expression in cancer

TL;DR: The viRNAtrap pipeline as discussed by the authors uses a deep learning model trained to discriminate viral RNAseq reads to explore viral expression in cancers and apply it to 14 cancer types from The Cancer Genome Atlas (TCGA).
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Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues

TL;DR: Analysis of country-specific, tissue-matched cancer-AID incidence rate sex bias data pairs finds that the sex biases observed in the incidence of AIDs and cancers that occur in the same tissue are positively correlated across human tissues.
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Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Long-Term Risk of Immune-Related diseases

TL;DR: In this paper , the long-term health risks associated with Glucose-6-phosphate dehydrogenase (G6PD) deficiency had not been studied in a large population.
Posted ContentDOI

Ribovore: ribosomal RNA sequence analysis for GenBank submissions and database curation

TL;DR: Ribovore as mentioned in this paper is a software package for sequence analysis of rRNA sequences that combines single-sequence and profile-based methods to improve GenBank processing and analysis of RRNA sequences.