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Alejandro A. Schäffer
Researcher at National Institutes of Health
Publications - 269
Citations - 98821
Alejandro A. Schäffer is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 74, co-authored 249 publications receiving 92583 citations. Previous affiliations of Alejandro A. Schäffer include Rice University & Bell Labs.
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Repurposing CAR targets in solid tumors via a pan-cancer single-cell transcriptome analysis
TL;DR: In this paper, the authors mined single cell transcriptomics datasets of solid tumors and surveyed many existing CAR targets, aiming to new solid tumor types in which these targets are differentially expressed in tumor cells and not on non-tumor cells within the tumor microenvironment, thus providing new repurposing opportunities.
Journal ArticleDOI
A deep learning approach reveals unexplored landscape of viral expression in cancer
Abdurrahman Elbasir,Ying Ye,Daniel E. Schäffer,Xue Hao,Jayamanna Wickramasinghe,Konstantinos Tsingas,Paul M. Lieberman,Qi Long,Quaid Morris,Rugang Zhang,Alejandro A. Schäffer,Noam Auslander +11 more
TL;DR: The viRNAtrap pipeline as discussed by the authors uses a deep learning model trained to discriminate viral RNAseq reads to explore viral expression in cancers and apply it to 14 cancer types from The Cancer Genome Atlas (TCGA).
Journal ArticleDOI
Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues
David R. Crawford,Sanju Sinha,Nishanth Ulhas Nair,Bríd M. Ryan,Jill S. Barnholtz-Sloan,Stephen M. Mount,Ayelet Erez,Kenneth Aldape,Philip E. Castle,Padma Sheila Rajagopal,Chi-Ping Day,Alejandro A. Schäffer,Eytan Ruppin +12 more
TL;DR: Analysis of country-specific, tissue-matched cancer-AID incidence rate sex bias data pairs finds that the sex biases observed in the incidence of AIDs and cancers that occur in the same tissue are positively correlated across human tissues.
Posted ContentDOI
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Long-Term Risk of Immune-Related diseases
Ariel Israel,Alejandro A. Schäffer,Matitiahu Berkovitch,David Ozeri,E. E. Merzon,Ilan Green,Avivit Golan-Cohen,Eytan Ruppin,Shlomo Vinker,Eli Magen +9 more
TL;DR: In this paper , the long-term health risks associated with Glucose-6-phosphate dehydrogenase (G6PD) deficiency had not been studied in a large population.
Posted ContentDOI
Ribovore: ribosomal RNA sequence analysis for GenBank submissions and database curation
Alejandro A. Schäffer,Richard McVeigh,Barbara Robbertse,Conrad L. Schoch,Anjanette Johnston,Beverly A. Underwood,Ilene Karsch-Mizrachi,Eric P. Nawrocki +7 more
TL;DR: Ribovore as mentioned in this paper is a software package for sequence analysis of rRNA sequences that combines single-sequence and profile-based methods to improve GenBank processing and analysis of RRNA sequences.