A
Alejandro A. Schäffer
Researcher at National Institutes of Health
Publications - 269
Citations - 98821
Alejandro A. Schäffer is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 74, co-authored 249 publications receiving 92583 citations. Previous affiliations of Alejandro A. Schäffer include Rice University & Bell Labs.
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Journal ArticleDOI
Protein database searches using compositionally adjusted substitution matrices
Stephen F. Altschul,John C. Wootton,E. Michael Gertz,Richa Agarwala,Aleksandr Morgulis,Alejandro A. Schäffer,Yi-Kuo Yu +6 more
TL;DR: This work has recently developed a general procedure for transforming a standard matrix into one appropriate for the comparison of two sequences with arbitrary, and possibly differing compositions.
Journal ArticleDOI
Database indexing for production MegaBLAST searches
Aleksandr Morgulis,George Coulouris,Yan Raytselis,Thomas L. Madden,Richa Agarwala,Alejandro A. Schäffer +5 more
TL;DR: A new version of the MegaBLAST module of BLAST that does the initial phase of finding short seeds for matches by searching a database index and a program makembindex that preprocesses the database into a data structure for rapid seed searching are developed.
Journal ArticleDOI
Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23
Mihael H. Polymeropoulos,J. J. Higgins,Lawrence I. Golbe,William G. Johnson,Susan E. Ide,Giuseppe Di Iorio,G. Sanges,Edward S. Stenroos,Lana T. Pho,Alejandro A. Schäffer,Alice M. Lazzarini,Robert L. Nussbaum,Roger C. Duvoisin +12 more
TL;DR: In this article, genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Zmax = 6.00 for marker D4S2380.
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A Homozygous CARD9 Mutation in a Family with Susceptibility to Fungal Infections
Erik-Oliver Glocker,André Hennigs,Mohammad Nabavi,Alejandro A. Schäffer,Cristina Woellner,Ulrich Salzer,Dietmar Pfeifer,Hendrik Veelken,Klaus Warnatz,F Tahami,Sarah Jamal,Annabelle Manguiat,Nima Rezaei,Ali Akbar Amirzargar,Alessandro Plebani,Nicole Hannesschläger,Olaf Gross,Jürgen Ruland,Bodo Grimbacher +18 more
TL;DR: Functional studies based on genetic reconstitution of myeloid cells from Card9(-/-) mice showed that the Q295X mutation impairs innate signaling from the antifungal pattern-recognition receptor dectin-1.
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Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency
Bodo Grimbacher,Andreas Hutloff,Michael Schlesier,Erik Glocker,Klaus Warnatz,Ruth Dräger,Hermann Eibel,Beate Fischer,Alejandro A. Schäffer,Hans W. Mages,Richard A. Kroczek,Hans H. Peter +11 more
TL;DR: The phenotype of human ICOS deficiency, which differs in key aspects from that of the ICOS−/− mouse, suggests a critical involvement of ICOS in T cell help for late B cell differentiation, class-switching and memory B cell generation.