A
Alejandro A. Schäffer
Researcher at National Institutes of Health
Publications - 269
Citations - 98821
Alejandro A. Schäffer is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 74, co-authored 249 publications receiving 92583 citations. Previous affiliations of Alejandro A. Schäffer include Rice University & Bell Labs.
Papers
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Journal ArticleDOI
Tumor Copy Number Deconvolution Integrating Bulk and Single-Cell Sequencing Data.
Haoyun Lei,Bochuan Lyu,E. Michael Gertz,Alejandro A. Schäffer,Xulian Shi,Kui Wu,Guibo Li,Liqin Xu,Yong Hou,Michael Dean,Russell Schwartz +10 more
TL;DR: New strategies for deconvolution and tumor phylogenetics combining limited amounts of bulk and single-cell data to gain some advantages of single- cell resolution with much lower cost, with specific focus on deconvolving genomic copy number data.
Book ChapterDOI
Dynamic Dictionary Matching with Failure Functions (Extended Abstract)
TL;DR: In the dynamic dictionary matching problem as mentioned in this paper, a dictionary D contains a set of patterns that can change over time by insertion and deletion of individual patterns, and the user also presents text strings and asks for all occurrences of any patterns in the text.
Journal ArticleDOI
A 1.3-Mb interval map of equine homologs of HSA2.
M. L. Wagner,Terje Raudsepp,Glenda Goh,Richa Agarwala,Alejandro A. Schäffer,Patricia K. Dranchak,Candice Brinkmeyer-Langford,Loren C. Skow,Bhanu P. Chowdhary,James R. Mickelson +9 more
TL;DR: The assignment of 140 new markers to the equine radiation hybrid (RH) map, and the anchoring of 24 of these markers to horse chromosomes by FISH are described, which have a three-fold increase in the number of mapped markers compared to previous maps of these chromosomes.
Journal ArticleDOI
HLA B44 is associated with decreased severity of autoimmune lymphoproliferative syndrome in patients with CD95 defects (ALPS type Ia).
Marla M. Vacek,Alejandro A. Schäffer,Joie Davis,Roxanne Fischer,Janet K. Dale,Sharon Adams,Sharon E. Straus,Jennifer M. Puck +7 more
TL;DR: The B44 allele may exert a protective role in ALPS, and among the healthier, mutation-bearing individuals, transmission of HLA B44 was significantly overrepresented (nominal P<0.0074) as compared to transmission in patients with severe clinical features of ALPS.
Journal ArticleDOI
Analysis of the bereavement effect after the death of a spouse in the Amish: a population-based retrospective cohort study
Ari Seifter,Sarabdeep Singh,Patrick F. McArdle,Kathleen A. Ryan,Alan R. Shuldiner,Alan R. Shuldiner,Braxton D. Mitchell,Braxton D. Mitchell,Alejandro A. Schäffer +8 more
TL;DR: It is concluded that bereavement effects remain apparent even in this socially cohesive Amish community and remarriage is associated with a significant decrease in the mortality risk among Amish individuals.