A
Alejandro A. Schäffer
Researcher at National Institutes of Health
Publications - 269
Citations - 98821
Alejandro A. Schäffer is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 74, co-authored 249 publications receiving 92583 citations. Previous affiliations of Alejandro A. Schäffer include Rice University & Bell Labs.
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Journal ArticleDOI
Second-Generation Integrated Genetic Linkage/Radiation Hybrid Maps of the Domestic Cat (Felis catus)
Marilyn Menotti-Raymond,Victor A. David,Zhao-hong Chen,K. A. Menotti,Shouheng Sun,Alejandro A. Schäffer,Richa Agarwala,James F. Tomlin,Stephen J. O'Brien,William J. Murphy +9 more
TL;DR: The integrated linkage and RH maps reveal approximately 110 conserved segments ordered between the human and feline genomes, and provide extensive anchored reference marker homologues that connect to the more gene dense human and mouse sequence maps, suitable for positional cloning applications.
Proceedings ArticleDOI
On the complexity of local search
TL;DR: The main results are these: Finding a local optimum under the Lin-Kernighan heuristic for the traveling salesman problem is PLS-complete, and a host of simple unweighted local optimality problems are P-complete.
Journal ArticleDOI
Single-Cell Genetic Analysis of Ductal Carcinoma in Situ and Invasive Breast Cancer Reveals Enormous Tumor Heterogeneity yet Conserved Genomic Imbalances and Gain of MYC during Progression
Kerstin Heselmeyer-Haddad,Lissa Y. Berroa Garcia,Amanda Bradley,Clarymar Ortiz-Melendez,Woei-Jyh Lee,Rebecca Christensen,Sheila A. Prindiville,Kathleen A. Calzone,Peter W. Soballe,Yue Hu,Salim A. Chowdhury,Russell Schwartz,Alejandro A. Schäffer,Thomas Ried +13 more
TL;DR: Despite considerable chromosomal instability, in most cases the evolution from DCIS to IDC is determined by recurrent patterns of genomic imbalances, consistent with a biological continuum.
Journal ArticleDOI
Genomic imbalances in the progression of endocrine pancreatic tumors.
Jianming Zhao,Holger Moch,Alexander F. Scheidweiler,Angela Baer,Alejandro A. Schäffer,Ernst J. M. Speel,Jürgen Roth,Philipp U. Heitz,Paul Komminoth +8 more
TL;DR: The most striking genomic changes which were enriched in metastases included gains of chromosomes 4 and 7 and losses of 21q, and chromosomal aberrations were found in significantly fewer nonmetastatic EPTs.
Journal ArticleDOI
ZNF341 controls STAT3 expression and thereby immunocompetence
Stefanie Frey-Jakobs,Julia M. Hartberger,Manfred Fliegauf,Claudia Bossen,Magdalena L. Wehmeyer,Johanna Charlotte Neubauer,Alla Bulashevska,Michele Proietti,Philipp Fröbel,Christina Nöltner,Linlin Yang,Jessica Rojas-Restrepo,Niko Langer,Sandra Winzer,Karin R. Engelhardt,Cristina Glocker,Dietmar Pfeifer,Adi Klein,Alejandro A. Schäffer,Irina Lagovsky,Irina Lagovsky,Idit Lachover-Roth,Vivien Béziat,Vivien Béziat,Anne Puel,Anne Puel,Anne Puel,Jean-Laurent Casanova,Bernhard Fleckenstein,Stephan Weidinger,Sara Sebnem Kilic,Ben-Zion Garty,Amos Etzioni,Bodo Grimbacher,Bodo Grimbacher +34 more
TL;DR: Nonsense mutations in ZNF341 account for the STAT3-like phenotype in four autosomal-recessive kindreds and reveal a previously unappreciated layer of transcriptional regulation controlling JAK-STAT signaling, a previously unrecognized regulator of immune homeostasis.