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Alejandro Abuin
Researcher at Lexicon Pharmaceuticals
Publications - 39
Citations - 2863
Alejandro Abuin is an academic researcher from Lexicon Pharmaceuticals. The author has contributed to research in topics: Polynucleotide & Gene. The author has an hindex of 16, co-authored 39 publications receiving 2744 citations. Previous affiliations of Alejandro Abuin include GlaxoSmithKline & Baylor College of Medicine.
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Journal ArticleDOI
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
John C. Clapham,Jonathan R.S. Arch,Helen Chapman,Andrea C. Haynes,Carolyn A. Lister,Gary B.T. Moore,Valerie Piercy,Sabrina A. Carter,Ines Lehner,Stephen A. Smith,Lee James Beeley,Robert James Godden,Nicole Herrity,Mark Skehel,Kumar Changani,Paul D. Hockings,David G. Reid,Sarah M. Squires,Jonathan P. Hatcher,Brenda K. Trail,Judy Latcham,Sohaila Rastan,Alexander J. Harper,Susana Cadenas,Julie A. Buckingham,Martin D. Brand,Alejandro Abuin +26 more
TL;DR: Evidence is provided that skeletal muscle UCP-3 has the potential to influence metabolic rate and glucose homeostasis in the whole animal by the creation of transgenic mice that overexpress human U CP-3 in skeletal muscle.
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Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.
L. Miguel Martins,L. Miguel Martins,Alastair Morrison,Kristina Klupsch,Valentina Fedele,Nicoleta Moisoi,Peter Teismann,Alejandro Abuin,Evelyn Grau,Martin Geppert,George P. Livi,Caretha L. Creasy,Alison Martin,Iain P. Hargreaves,Simon J.R. Heales,Hitoshi Okada,Sebastian Brandner,Jörg B. Schulz,Tak W. Mak,Julian Downward +19 more
TL;DR: Mammalian HtrA2/Omi is likely to function in vivo in a manner similar to that of its bacterial homologues DegS and DegP, which are involved in protection against cell stress, and not like the proapoptotic Reaper family proteins in Drosophila melanogaster.
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Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention
Brian Zambrowicz,Alejandro Abuin,Ramiro Ramirez-Solis,Lizabeth J. Richter,James Piggott,Hector BeltrandelRio,Eric C. Buxton,Joel Edwards,Rick Avery Finch,Carl Johan Friddle,Anupma Gupta,Gwenn M. Hansen,Yi Hu,Wenhu Huang,Crystal Jaing,Billie Key,Peter Kipp,Buckley Kohlhauff,Zhi Qing Ma,Diane Markesich,Robert J. H. Payne,David Potter,Ny Qian,Joseph Shaw,Jeff Schrick,Zheng Zheng Shi,Mary Jean Sparks,Isaac Van Sligtenhorst,Peter Vogel,Wade Walke,Nianhua Xu,Qichao Zhu,Christophe Person,Arthur T. Sands +33 more
TL;DR: It is demonstrated that Wnk1 is a regulator of blood pressure critical for development and illustrate the utility of a functional screen driven by a sequence-based mutagenesis approach.
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A mouse knockout library for secreted and transmembrane proteins.
Tracy Tang,Li Li,Jerry Tang,Yun Li,Wei Yu Lin,Flavius Martin,Deanna Grant,Mark J. Solloway,Leon Parker,Weilan Ye,William F. Forrest,Nico Ghilardi,Tamas Oravecz,Kenneth A. Platt,Dennis S. Rice,Gwenn M. Hansen,Alejandro Abuin,Derek E. Eberhart,Paul J. Godowski,Kathleen H. Holt,Andrew S. Peterson,Brian Zambrowicz,Frederic J. de Sauvage +22 more
TL;DR: The authors used retroviral insertion or homologous recombination to disrupt 472 genes encoding secreted and membrane proteins in mice, providing a resource for studying a large fraction of this important class of drug target.
Journal ArticleDOI
High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC
TL;DR: A mouse homologue of the human gene for XP group C is isolated and generated XPC-deficient mice by using embryonic stem cell technology and homozygous xpcm1 mutant mice display a spectrum of ultraviolet-exposure-related pathological skin and eye changes consistent with the human disease xeroderma pigmentosum group C.