Alejandro Athie

TL;DR: It is shown that Pint is a ubiquitously expressed lincRNA that is finely regulated by p53, and its expression significantly correlates with the same cellular pathways as the mouse ortholog, including the p53 pathway.

TL;DR: The signature defined by p53-regulated lncRNAs supports their potential use in the clinic as biomarkers and therapeutic targets and establishes a positive regulatory feedback loop that enhances p53 tumour suppressor activity.

TL;DR: This work finds that LINC-PINT is downregulated in multiple types of cancer and acts as a tumor suppressor lncRNA by reducing the invasive phenotype of cancer cells, and proposes a new mechanism where the lnc RNA regulates the availability of free PRC2 at the proximity of co-regulated genomic loci.

TL;DR: Using an in vivo model for increasing excitatory activity in the cortex and the hippocampus indicates that the distribution of some miRNAs can be modulated by enhanced neuronal (epileptogenic) activity, demonstrating the dynamic modulation in the local distribution of miRNAAs from the adult brain, which may play key roles in controlling localized protein synthesis at the synapse.

TL;DR: A previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), is described that is transcriptionally activated by MYC and upregulated in multiple cancer types and reveals a direct role for an lnc RNA in the establishment of sister chromatid cohesion by modulating DDX11 enzymatic activity.