M
Mavis R. Swerdel
Researcher at Rutgers University
Publications - 32
Citations - 1810
Mavis R. Swerdel is an academic researcher from Rutgers University. The author has contributed to research in topics: Metallothionein & Induced pluripotent stem cell. The author has an hindex of 16, co-authored 32 publications receiving 1613 citations. Previous affiliations of Mavis R. Swerdel include University of Minnesota & University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
Multiple knockout mouse models reveal lincRNAs are required for life and brain development
Martin Sauvageau,Martin Sauvageau,Loyal A. Goff,Loyal A. Goff,Loyal A. Goff,Simona Lodato,Simona Lodato,Boyan B. Bonev,Boyan B. Bonev,Abigail F. Groff,Abigail F. Groff,Chiara Gerhardinger,Chiara Gerhardinger,Diana B. Sanchez-Gomez,Ezgi Hacisuleyman,Ezgi Hacisuleyman,Eric Li,Matthew Spence,Stephen C. Liapis,Stephen C. Liapis,William Mallard,William Mallard,Michael A. Morse,Michael A. Morse,Mavis R. Swerdel,Michael F D’Ecclessis,Jennifer C. Moore,Venus Lai,Guochun Gong,George D. Yancopoulos,David Frendewey,Manolis Kellis,Manolis Kellis,Ronald P. Hart,David M. Valenzuela,Paola Arlotta,Paola Arlotta,John L. Rinn,John L. Rinn,John L. Rinn +39 more
TL;DR: It is demonstrated that lncRNAs play critical roles in vivo and provides a framework and impetus for future larger-scale functional investigation into the roles of lncRNA molecules.
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Differential regulation of microRNA stability
Sophie Bail,Mavis R. Swerdel,Hudan Liu,Xinfu Jiao,Loyal A. Goff,Ronald P. Hart,Megerditch Kiledjian +6 more
TL;DR: It is demonstrated that although most miRNA appear to be stable, like mRNAs, miRNAs possess differential stability in human cells and it is found that miR-382, a miRNA that contributes to HIV-1 provirus latency, is unstable in cells.
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EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia
Jiali Li,Ronald P. Hart,Elyse M. Mallimo,Mavis R. Swerdel,Alexander W. Kusnecov,Karl Herrup,Karl Herrup +6 more
TL;DR: Increased trimethylation of histone H3 on Lys27 (H3K27me3) mediated by polycomb repressive complex 2 (PRC2) is also important in the A-T phenotype, and ATM-mediated phosphorylation of EZH2 on Ser734 reduces protein stability.
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Ago2 Immunoprecipitation Identifies Predicted MicroRNAs in Human Embryonic Stem Cells and Neural Precursors
Loyal A. Goff,Loyal A. Goff,Jonathan Davila,Mavis R. Swerdel,Jennifer C. Moore,Rick I. Cohen,Hao Wu,Yi E. Sun,Ronald P. Hart +8 more
TL;DR: A large number of new microRNA genes, the majority of which are less conserved than their canonical counterparts, likely represent evolutionarily recent regulators of early differentiation.
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Differentiating Human Multipotent Mesenchymal Stromal Cells Regulate microRNAs: Prediction of microRNA Regulation by PDGF During Osteogenesis
Loyal A. Goff,Shayne Boucher,Christopher L. Ricupero,Sara J. Fenstermacher,Mavis R. Swerdel,Lucas G. Chase,Christopher C. Adams,Jonathan D. Chesnut,Uma Lakshmipathy,Ronald P. Hart +9 more
TL;DR: It is demonstrated that a subset of microRNAs regulated during osteogenic differentiation of MSCs is responsive to perturbation of the PDGF pathway, which begins to link regulated molecules with specific cellular pathways.