A
Alejandro Czernikier
Researcher at University of Buenos Aires
Publications - 5
Citations - 20
Alejandro Czernikier is an academic researcher from University of Buenos Aires. The author has contributed to research in topics: Immunology & Medicine. The author has an hindex of 1, co-authored 2 publications receiving 5 citations.
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Journal ArticleDOI
Hepatitis C Virus (HCV) Clearance After Treatment With Direct-Acting Antivirals in Human Immunodeficiency Virus (HIV)-HCV Coinfection Modulates Systemic Immune Activation and HIV Transcription on Antiretroviral Therapy
Yanina Alexandra Ghiglione,María Laura Polo,Alejandra Urioste,Ajantha Rhodes,Alejandro Czernikier,César Ariel Trifone,María Florencia Quiroga,Alicia Sisto,Patricia Patterson,Horacio Salomón,María José Rolón,Sonia Bakkour,Sharon R Lewin,Sharon R Lewin,Gabriela Turk,Natalia Laufer +15 more
TL;DR: Insight is provided into the effects of HCV coinfection in HIV persistence and regards coinfected subjects as a population in which HIV remission might prove to be more challenging.
Journal ArticleDOI
SARS-CoV-2 humoral and cellular immune responses in COVID-19 convalescent individuals with HIV
Denise Giannone,María Belén Vecchione,Alejandro Czernikier,Maria Laura Polo,Virginia González Polo,Leonel Cruces,Yanina Alexandra Ghiglione,S. Balinotti,Yesica Longueira,Gabriela Turk,Natalia Laufer,María Florencia Quiroga +11 more
TL;DR: The authors reported that people with HIV (PWH) presented similar levels of anti-SARS-Cov-2 antibodies compared to HIV-negative individuals and that HIV infection is neither a risk factor for moderate or severe COVID-19 nor for mortality.
Journal ArticleDOI
Pre-cART Immune Parameters in People Living With HIV Might Help Predict CD8+ T-Cell Characteristics, Inflammation Levels, and Reservoir Composition After Effective cART
Jimena Salido,Alejandro Czernikier,César Ariel Trifone,María Laura Polo,María Inés Figueroa,Alejandra Urioste,Pedro Cahn,Omar Sued,Horacio Salomón,Natalia Laufer,Yanina Alexandra Ghiglione,Gabriela Turk +11 more
TL;DR: Identifying factors related to CD8TC and CD4TC quality before cART initiation that associate with the persistence ofCD8TC antiviral response after cART, inflammation levels, and the size of the viral reservoir is provided.
Journal ArticleDOI
A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection
Julia Rubione,Paula Soledad Pérez,Alejandro Czernikier,Gabriel Duette,Federico Pehuen Pereyra Gerber,Jimena Salido,Martina P. Fabiano,Yanina Alexandra Ghiglione,Gabriela Turk,Natalia Laufer,Alejandro J. Cagnoni,Juan M. Pérez Sáez,Joaquín Pedro Merlo,Carla A. Pascuale,Juan C. Stupirski,Omar Sued,Manuel Varas-Godoy,Sharon R Lewin,Karina Mariño,Gabriel A. Rabinovich,Matias Ostrowski +20 more
TL;DR: A central role is identified for galectin-1 (Gal-1), a glycan-binding protein released in response to extracellular vesicles (EVs), in modulating the activity of HIV reservoir, thus shaping chronic immune activation in HIV-infected patients.
Journal ArticleDOI
Macrophage Migration Inhibitory Factor (MIF) Promotes Increased Proportions of the Highly Permissive Th17-like Cell Profile during HIV Infection
César Ariel Trifone,Lucia Baquero,Alejandro Czernikier,Paula Benencio,Lin Leng,Natalia Laufer,María Florencia Quiroga,Richard Bucala,Yanina Alexandra Ghiglione,Gabriela Turk +9 more
TL;DR: MIF may contribute to viral pathogenesis by generating a microenvironment enriched in activating mediators and Th17-like CD4TLs, which are known to be highly susceptible to HIV-1 infection and relevant to viral persistence.