A
Alem Haile
Researcher at Washington University in St. Louis
Publications - 9
Citations - 1483
Alem Haile is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Vaccination & Antibody. The author has an hindex of 7, co-authored 9 publications receiving 374 citations.
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Journal ArticleDOI
SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses.
Jackson S. Turner,Jane A. O’Halloran,Elizaveta Kalaidina,Wooseob Kim,Aaron J. Schmitz,Julian Q. Zhou,Tingting Lei,Mahima Thapa,Rita E. Chen,James Brett Case,Fatima Amanat,Adriana M Rauseo,Alem Haile,Xuping Xie,Michael K. Klebert,Teresa Suessen,William D. Middleton,Pei Yong Shi,Florian Krammer,Sharlene A. Teefey,Michael S. Diamond,Rachel M. Presti,Ali H. Ellebedy +22 more
TL;DR: In this article, the authors examined antigen-specific B-cell responses in peripheral blood and draining lymph nodes in 14 individuals who had received 2-doses of BNT162b2, an mRNA-based vaccine that encodes the full-length SARS-CoV-2 spike (S) gene1.
Journal ArticleDOI
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans.
Jackson S. Turner,Wooseob Kim,Elizaveta Kalaidina,Charles W. Goss,Adriana M Rauseo,Aaron J. Schmitz,Lena Hansen,Lena Hansen,Alem Haile,Michael K. Klebert,Iskra Pusic,Jane A. O’Halloran,Rachel M. Presti,Ali H. Ellebedy +13 more
TL;DR: In this paper, the authors show that mild SARS-CoV-2 infection induces long-lived bone marrow plasma cells that correlate with anti-SARS-coV2 spike protein antibody titres in individuals who have recovered from COVID-19.
Journal ArticleDOI
Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2 : A Prospective Cohort Study.
Parakkal Deepak,Wooseob Kim,Michael A. Paley,Monica Yang,Alexander Carvidi,Emanuel G Demissie,Alia A El-Qunni,Alem Haile,Katherine Huang,Baylee Kinnett,Mariel J. Liebeskind,Zhuoming Liu,Lily E McMorrow,Diana Paez,Niti Pawar,Dana C. Perantie,Rebecca E Schriefer,Shannon E Sides,Mahima Thapa,Maté Gergely,Suha Abushamma,Sewuese E. Akuse,Michael K. Klebert,Lynne M. Mitchell,Darren Nix,Jonathan Graf,Kimberly E. Taylor,Salim Chahin,Matthew A. Ciorba,Patricia P. Katz,Mehrdad Matloubian,Jane A. O’Halloran,Rachel M. Presti,Gregory F. Wu,Sean P. J. Whelan,William Buchser,Lianne S. Gensler,Mary C. Nakamura,Ali H. Ellebedy,Alfred H.J. Kim +39 more
TL;DR: In this paper, the immunogenicity of mRNA-based SARS-CoV-2 vaccines in patients with chronic inflammatory disease (CID) was evaluated in an observational cohort study.
Journal ArticleDOI
Human germinal centres engage memory and naive B cells after influenza vaccination.
Jackson S. Turner,Julian Q. Zhou,Julianna Han,Aaron J. Schmitz,Amena A. Rizk,Wafaa B. Alsoussi,Tingting Lei,Mostafa Amor,Katherine M. McIntire,Philip Meade,Shirin Strohmeier,Rafael I. Brent,Sara T. Richey,Alem Haile,Yuhe R. Yang,Michael K. Klebert,Teresa Suessen,Sharlene A. Teefey,Rachel M. Presti,Florian Krammer,Steven H. Kleinstein,Andrew B. Ward,Ali H. Ellebedy +22 more
TL;DR: Influenza virus vaccination in humans can elicit a germinal centre reaction that recruits B cell clones that can target new epitopes, thereby broadening the spectrum of vaccine-induced protective antibodies.
Posted ContentDOI
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans.
Jackson S. Turner,Wooseob Kim,Elizaveta Kalaidina,Charles W. Goss,Adriana M Rauseo,Aaron J. Schmitz,Lena Hansen,Lena Hansen,Alem Haile,Michael K. Klebert,Iskra Pusic,Jane A. O’Halloran,Rachel M. Presti,Ali H. Ellebedy +13 more
TL;DR: It is shown that robust antigen specific long-lived BMPCs and MBCs are induced after mild SARS-CoV-2 infection of humans.