S
Steven H. Kleinstein
Researcher at Yale University
Publications - 190
Citations - 12502
Steven H. Kleinstein is an academic researcher from Yale University. The author has contributed to research in topics: Somatic hypermutation & Immune system. The author has an hindex of 49, co-authored 167 publications receiving 9450 citations. Previous affiliations of Steven H. Kleinstein include Princeton University.
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Journal ArticleDOI
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.
Ping-Chih Ho,Jessica D. Bihuniak,Andrew N. Macintyre,Matthew M. Staron,Xiaojing Liu,Robert A. Amezquita,Yao Chen Tsui,Yao Chen Tsui,Guoliang Cui,Goran Micevic,Jose C. Perales,Steven H. Kleinstein,E. Dale Abel,Karl L. Insogna,Stefan Feske,Jason W. Locasale,Marcus Bosenberg,Jeffrey C. Rathmell,Susan M. Kaech,Susan M. Kaech +19 more
TL;DR: New metabolic checkpoints for T cell activity are uncovered and it is demonstrated that metabolic reprogramming of tumor-reactive T cells can enhance anti-tumor T cell responses, illuminating new forms of immunotherapy.
Journal ArticleDOI
Two levels of protection for the B cell genome during somatic hypermutation
Man Liu,Jamie L. Duke,Daniel J. Richter,Daniel J. Richter,Carola G. Vinuesa,Christopher C. Goodnow,Steven H. Kleinstein,David G. Schatz +7 more
TL;DR: It is demonstrated that AID acts broadly on the genome, with the ultimate distribution of mutations determined by a balance between high-fidelity and error-prone DNA repair, and numerous genes linked to B cell tumorigenesis are deaminated by AID but escape acquisition of most mutations.
Journal ArticleDOI
Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data
Namita Gupta,Jason A. Vander Heiden,Mohamed Uduman,Daniel Gadala-Maria,Gur Yaari,Steven H. Kleinstein +5 more
TL;DR: A suite of utilities, Change-O, which provides tools for advanced analyses of large-scale Ig repertoire sequencing data, and enables the seamless integration of multiple analyses into a single workflow.
Journal ArticleDOI
Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone
Steven M. Kerfoot,Gur Yaari,Jaymin R. Patel,Kody L. Johnson,David Gonzalez,Steven H. Kleinstein,Ann M. Haberman +6 more
TL;DR: Ag-specific B cells are required for the maintenance of the PD-1, ICOS, and GL7 Tfh cell phenotype within the follicle, but not for their initial differentiation in the IF zone.
Journal ArticleDOI
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes
Joel N. H. Stern,Gur Yaari,Gur Yaari,Jason A. Vander Heiden,George M. Church,William Donahue,Rogier Q. Hintzen,Anita Huttner,Jon D. Laman,Rashed M. Nagra,Alyssa Nylander,David Pitt,Sriram Ramanan,Bilal A. Siddiqui,Francois Vigneault,Steven H. Kleinstein,David A. Hafler,Kevin C. O’Connor +17 more
TL;DR: New evidence is provided that B cells traffic freely across the tissue barrier, with the majority of B cell maturation occurring outside of the CNS in the secondary lymphoid tissue.