Alessandra Bolotta

TL;DR: Some Au clinical features appear to be correlated with these findings; in particular, hyperactivity score appears to be related with some parameters of the lipidomic profile and membrane fluidity, which could prompt the development of palliative therapeutic protocols.

TL;DR: Data driven combination of these biomarkers perturbed by proteotoxic stress, plasma protein AGEs and DT, gave diagnostic algorithms of high sensitivity and specificity for ASD.

TL;DR: Red blood cells from people affected by autism spectrum disorders (ASDs) are analyzed and RBC shape alterations were independent of the anticoagulant used (Na2-EDTA or heparin) and of different handling procedures preceding glutaraldehyde fixation, thus suggesting that they were not artefactual.

TL;DR: Receiver Operating Characteristic (ROC) analysis is applied to some of the previously published data and discusses the increased diagnostic value of combining more variables in one ROC curve analysis, and the use of biomarkers as a tool for advancing the understanding of nonsyndromic ASD.

TL;DR: Autistic children had normal plasma and urinary thiamine levels whereas plasma TPP concentration was decreased, and the latter may be linked to abnormal tissue handling and/or absorption from gut microbiota of TPP which warrants further investigation.