G
Giulio Cossu
Researcher at University of Manchester
Publications - 273
Citations - 27429
Giulio Cossu is an academic researcher from University of Manchester. The author has contributed to research in topics: Myogenesis & Stem cell. The author has an hindex of 76, co-authored 268 publications receiving 25826 citations. Previous affiliations of Giulio Cossu include Seattle Children's Research Institute & Manchester Academic Health Science Centre.
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Journal ArticleDOI
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
Giuliana Ferrari,Gabriella Cusella,Gabriella Cusella,D. De Angelis,D. De Angelis,M. Coletta,M. Coletta,Egle Paolucci,Egle Paolucci,Anna Stornaiuolo,Anna Stornaiuolo,Giulio Cossu,Giulio Cossu,Fulvio Mavilio,Fulvio Mavilio +14 more
TL;DR: Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers.
Journal ArticleDOI
Isolation and Expansion of Adult Cardiac Stem Cells From Human and Murine Heart
Elisa Messina,Luciana De Angelis,Giacomo Frati,Stefania Morrone,Stefano Chimenti,Fabio Fiordaliso,Monica Salio,Massimo Battaglia,Michael V.G. Latronico,M. Coletta,E. Vivarelli,Luigi Frati,Giulio Cossu,Alessandro Giacomello +13 more
TL;DR: The isolation of undifferentiated cells that grow as self-adherent clusters (that are termed “cardiospheres”) from subcultures of postnatal atrial or ventricular human biopsy specimens and from murine hearts are described.
Journal ArticleDOI
Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells.
Arianna Dellavalle,Maurilio Sampaolesi,Rossana Tonlorenzi,Enrico Tagliafico,Benedetto Sacchetti,Laura Perani,Anna Innocenzi,Beatriz G. Gálvez,Graziella Messina,Roberta Morosetti,Sheng Li,Marzia Belicchi,Giuseppe M. Peretti,Jeffrey S. Chamberlain,Woodring E. Wright,Yvan Torrente,Stefano Ferrari,Paolo Bianco,Giulio Cossu +18 more
TL;DR: Data show that myogenic precursors, distinct from satellite cells, are associated with microvascular walls in the human skeletal muscle, may represent a correlate of embryonic 'mesoangioblasts' present after birth and may be a promising candidate for future cell-therapy protocols in patients.
Journal ArticleDOI
Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD.
TL;DR: P Pax-3 and Myf-5 define two distinct myogenic pathways, and MyoD acts genetically downstream of these genes for myogenesis in the body, and this genetic hierarchy does not appear to operate for head muscle formation.
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Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs.
Maurilio Sampaolesi,Stéphane Blot,Giuseppe D'Antona,Nicolas Granger,Rossana Tonlorenzi,Anna Innocenzi,Paolo Mognol,Jean-Laurent Thibaud,Beatriz G. Gálvez,Inès Barthélémy,Laura Perani,Sara Mantero,Maria Guttinger,Orietta Pansarasa,Chiara Rinaldi,M. Gabriella Cusella De Angelis,Yvan Torrente,Claudio Bordignon,Roberto Bottinelli,Giulio Cossu +19 more
TL;DR: It is reported that intra-arterial delivery of wild-type canine mesoangioblasts (vessel-associated stem cells) results in an extensive recovery of dystrophin expression, normal muscle morphology and function, and a remarkable clinical amelioration and preservation of active motility.