Alessia Loffreda

TL;DR: Single-molecule tracking is used to directly demonstrate that p53 acetylation modulates promoter residence time and transcriptional activity and proposes a model in which the modification state of the transcription factor determines the coupling between transcription factor abundance and transcriptionAL activity by tuning the transcription factors residence time on target sites.

TL;DR: This review illustrates several different mechanisms through which pre-mRNA splicing and genomic stability can influence each other and specifically focuses on the role of splicing factors in the DNA damage response and how activation of the DDR can influence the activity ofsplicing factors.

TL;DR: A screen for Bcl-xL-interacting membrane proteins let us identify a novel proapoptotic protein whose activity is strongly counteracted exclusively by membrane targeted Bcl -xL.

TL;DR: It is shown that low-affinity binding sites act as a competitive reservoir in vivo from which transcription factors are released by mitogen-activated protein kinase-stimulated acetylation to promote increased occupancy of their regulatory elements.

TL;DR: This review will highlight recent advances in the understanding of the role of RBPs in the regulation of the maturation and the function of miRNAs in the context of neuronal development and function.