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Alexander McCampbell
Researcher at Merck & Co.
Publications - 10
Citations - 2558
Alexander McCampbell is an academic researcher from Merck & Co.. The author has contributed to research in topics: Trinucleotide repeat expansion & Histone deacetylase 5. The author has an hindex of 6, co-authored 9 publications receiving 2454 citations. Previous affiliations of Alexander McCampbell include National Institutes of Health.
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Journal ArticleDOI
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
Joan S. Steffan,László Bodai,Judit Pallos,Marnix Poelman,Alexander McCampbell,Barbara L. Apostol,Alexsey Kazantsev,Emily Schmidt,Ya-Zhen Zhu,Marilee Greenwald,Riki Kurokawa,David E. Housman,George R. Jackson,J. Lawrence Marsh,Leslie M. Thompson +14 more
TL;DR: It is shown that the polyglutamine-containing domain of Htt, Htt exon 1 protein (Httex1p), directly binds the acetyltransferase domains of two distinct proteins: CREB-binding protein (CBP) and p300/CBP-associated factor (P/CAF).
Journal ArticleDOI
CREB-binding protein sequestration by expanded polyglutamine
Alexander McCampbell,J. Paul Taylor,Addis A. Taye,Jon Robitschek,Mei Li,Jessica L. Walcott,Diane E. Merry,Yaohui Chai,Henry L. Paulson,Gen Sobue,Kenneth H. Fischbeck +10 more
TL;DR: Evidence is presented that CREB-binding protein (CBP), a transcriptional co-activator that orchestrates nuclear response to a variety of cell signaling cascades, is incorporated into nuclear inclusions formed by polyglutamine-containing proteins in cultured cells, transgenic mice and tissue from patients with SBMA.
Journal ArticleDOI
Histone deacetylase inhibitors reduce polyglutamine toxicity
Alexander McCampbell,Addis A. Taye,Leslie Whitty,Ellen B. Penney,Joan S. Steffan,Kenneth H. Fischbeck +5 more
TL;DR: It is suggested that nuclear accumulation of polyglutamine can lead to altered protein acetylation in neurons and indicate a novel therapeutic strategy for polyglUTamine disease.
Journal ArticleDOI
Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation
Lei Ma,Matthew A. Seager,Marion Wittmann,Marlene A. Jacobson,Denise J. Bickel,Maryann Burno,K. H. Jones,Valerie Kuzmick Graufelds,Guangping Xu,Michelle Pearson,Alexander McCampbell,Renee C. Gaspar,Paul J. Shughrue,Andrew Danziger,Christopher P. Regan,Rose Flick,Danette Pascarella,Susan L. Garson,Scott M. Doran,Constantine Kreatsoulas,Lone Veng,Craig W. Lindsley,William D. Shipe,Scott D. Kuduk,Cyrille Sur,Gene G. Kinney,Guy R. Seabrook,William J. Ray +27 more
TL;DR: Benzyl quinolone carboxylic acid exploits an allosteric potentiation mechanism to provide selectivity for the M1 receptor and represents a promising therapeutic strategy for cognitive disorders.
Journal ArticleDOI
A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid.
Mary J. Savage,Juliya Kalinina,Abigail Wolfe,Katherine Tugusheva,Rachel Korn,Tanesha Cash-Mason,Jill W. Maxwell,Nathan G. Hatcher,Sharie J. Haugabook,Guoxin Wu,Bonnie J. Howell,John J. Renger,Paul J. Shughrue,Alexander McCampbell +13 more
TL;DR: A significant 3- to 5-fold increase in Aβ oligomers in human AD CSF compared with comparably aged controls was demonstrated, suggesting reasonable discriminatory power for the AD state and the potential for utility as a diagnostic marker.