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Alexander Pflug
Researcher at University of Tromsø
Publications - 18
Citations - 1336
Alexander Pflug is an academic researcher from University of Tromsø. The author has contributed to research in topics: Polymerase & Transcription (biology). The author has an hindex of 12, co-authored 13 publications receiving 1121 citations. Previous affiliations of Alexander Pflug include Unit of Virus Host Cell Interactions & Centre national de la recherche scientifique.
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Journal ArticleDOI
Structure of influenza A polymerase bound to the viral RNA promoter
TL;DR: The crystal structure of the heterotrimeric bat influenza A polymerase, comprising subunits PA, PB1 and PB2, bound to its viral RNA promoter is presented, laying the basis for an atomic-level mechanistic understanding of the many functions of influenza polymerase and opens new opportunities for anti-influenza drug design.
Journal ArticleDOI
Structural insight into cap-snatching and RNA synthesis by influenza polymerase
Stefan Reich,Delphine Guilligay,Alexander Pflug,Hélène Malet,Imre Berger,Thibaut Crépin,Darren J. Hart,Thomas Lunardi,Max H. Nanao,Rob W.H. Ruigrok,Stephen Cusack +10 more
TL;DR: Crystal structures of bat influenza A and human influenza B polymerases (FluA and FluB), bound to the viral RNA promoter, are used to give mechanistic insight into these distinct processes.
Journal ArticleDOI
Structural insights into RNA synthesis by the influenza virus transcription-replication machine.
TL;DR: This review focusses on the new insights that recent crystal structures have given into the detailed molecular mechanisms by which the polymerase performs both transcription and replication of the vRNA genome.
Journal ArticleDOI
Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains.
Eric Thierry,Delphine Guilligay,Jan Kosinski,Thomas Bock,Stephanie Gaudon,Adam Round,Alexander Pflug,Narin Hengrung,Kamel El Omari,Florence Baudin,Darren J. Hart,Martin Beck,Stephen Cusack +12 more
TL;DR: A FluB polymerase structure with a bound complementary cRNA 5′ end that exhibits a major rearrangement of the subdomains within the C-terminal two-thirds of PB2 (PB2-C) is presented.
Journal ArticleDOI
Structural basis of an essential interaction between influenza polymerase and Pol II CTD
Maria Lukarska,Guillaume Fournier,Guillaume Fournier,Guillaume Fournier,Alexander Pflug,Patricia Resa-Infante,Stefan Reich,Nadia Naffakh,Nadia Naffakh,Nadia Naffakh,Stephen Cusack +10 more
TL;DR: It is concluded that direct binding of FluPol to the SeP5 Pol II CTD is fine-tuned to allow efficient viral transcription and proposed that the CTD-binding site on FluPol could be targeted for antiviral drug development.