H
Hélène Malet
Researcher at University of Grenoble
Publications - 32
Citations - 2953
Hélène Malet is an academic researcher from University of Grenoble. The author has contributed to research in topics: RNA & Polymerase. The author has an hindex of 20, co-authored 29 publications receiving 2577 citations. Previous affiliations of Hélène Malet include Centre national de la recherche scientifique & Unit of Virus Host Cell Interactions.
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Journal ArticleDOI
Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution
Thai Leong Yap,T. Xu,Yen Liang Chen,Hélène Malet,Marie-Pierre Egloff,Bruno Canard,Subhash G. Vasudevan,Julien Lescar,Julien Lescar +8 more
TL;DR: The structure of the NS5 nuclear localization sequences, previously thought to fold into a separate domain, form an integral part of the polymerase subdomains and reveals the presence of two zinc ion binding motifs, which should inform and accelerate the structure-based design of antiviral compounds against dengue virus.
Journal ArticleDOI
Structural insight into cap-snatching and RNA synthesis by influenza polymerase
Stefan Reich,Delphine Guilligay,Alexander Pflug,Hélène Malet,Imre Berger,Thibaut Crépin,Darren J. Hart,Thomas Lunardi,Max H. Nanao,Rob W.H. Ruigrok,Stephen Cusack +10 more
TL;DR: Crystal structures of bat influenza A and human influenza B polymerases (FluA and FluB), bound to the viral RNA promoter, are used to give mechanistic insight into these distinct processes.
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Structure and functionality in flavivirus NS-proteins: Perspectives for drug design
Michela Bollati,Karin Alvarez,Rene Assenberg,Cécile Baronti,Bruno Canard,Shelley Cook,Bruno Coutard,Etienne Decroly,Xavier de Lamballerie,Ernest A. Gould,Gilda Grard,Jonathan M. Grimes,Rolf Hilgenfeld,Anna M. Jansson,Hélène Malet,Erika J. Mancini,Eloise Mastrangelo,Andrea Mattevi,Mario Milani,Gregory Moureau,Johan Neyts,Raymond J. Owens,Jingshan Ren,Barbara Selisko,Silvia Speroni,Holger Steuber,David I. Stuart,Torsten Unge,Martino Bolognesi +28 more
TL;DR: Structural and functional aspects emerging from the characterization of two main components (NS3 and NS5 proteins) of the flavivirus replication complex are reviewed to shed light on the design and development of antiviral drug leads.
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Structural and Functional Basis for ADP-Ribose and Poly(ADP-Ribose) Binding by Viral Macro Domains
Marie-Pierre Egloff,Hélène Malet,Ákos Putics,Maarit Heinonen,Hélène Dutartre,Antoine Frangeul,Arnaud Gruez,Valérie Campanacci,Christian Cambillau,John Ziebuhr,John Ziebuhr,Tero Ahola,Bruno Canard +12 more
TL;DR: In this paper, the crystal structure of the SARS-CoV macro domain was determined at 1.8-Angstroms resolution in complex with ADP-ribose.
Journal ArticleDOI
Crystal Structure of the RNA Polymerase Domain of the West Nile Virus Non-structural Protein 5
Hélène Malet,Marie-Pierre Egloff,Barbara Selisko,Rebecca Elizabeth Butcher,Peter J. Wright,Michael S. Roberts,Arnaud Gruez,Gerlind Sulzenbacher,Clemens Vonrhein,Gérard Bricogne,Jason M. Mackenzie,Alexander A. Khromykh,Andrew D. Davidson,Bruno Canard +13 more
TL;DR: The Flaviv virus RdRp domain structure determined here should facilitate both the design of anti-Flavivirus drugs and structure-function studies of the Flavivirus replication complex in which the multifunctional NS5 protein plays a central role.