A
Alexander Schmittel
Researcher at Charité
Publications - 103
Citations - 4815
Alexander Schmittel is an academic researcher from Charité. The author has contributed to research in topics: Cancer & Antigen. The author has an hindex of 38, co-authored 101 publications receiving 4535 citations. Previous affiliations of Alexander Schmittel include Free University of Berlin.
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Journal ArticleDOI
The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial
Markus M. Heiss,Pawel Murawa,Piotr Koralewski,Elzbieta Kutarska,Olena O. Kolesnik,Vladimir V. Ivanchenko,Alexander S. Dudnichenko,Birute Aleknaviciene,Arturas Razbadauskas,Martin Gore,Elena Ganea-Motan,Tudor Ciuleanu,Pauline Wimberger,Alexander Schmittel,Barbara Schmalfeldt,Alexander Burges,Carsten Bokemeyer,Horst Lindhofer,Angelika Lahr,Simon L. Parsons +19 more
TL;DR: Catumaxomab showed a clear clinical benefit in patients with malignant ascites secondary to epithelial cancers, especially gastric cancer, with an acceptable safety profile.
Journal ArticleDOI
CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia.
Carmen Scheibenbogen,Anne Letsch,Eckhard Thiel,Alexander Schmittel,Volker Mailaender,Steffi Baerwolf,Dirk Nagorsen,Ulrich Keilholz +7 more
TL;DR: The results provide for the first time evidence for spontaneous T-cell reactivity against defined antigens in AML patients and support the immunogenicity of WT1 and proteinase 3 in acute leukemia patients and the potential usefulness of these antIGens for leukemia vaccines.
Journal ArticleDOI
Fatal hepatitis B virus reactivation by an escape mutant following rituximab therapy
Timm H. Westhoff,Friederike Jochimsen,Alexander Schmittel,Marina Stoffler-Meilicke,Jurgen H Schafer,Walter Zidek,Wolfram H. Gerlich,Eckhard Thiel +7 more
TL;DR: The chimeric monoclonal anti-CD20 antibody rituximab targets and destroys B lymphocytes and is used increasingly in the treatment of B-cell non-Hodgkin lymphoma.
Journal ArticleDOI
Prevention, Diagnosis, Therapy, and Follow-up of Lung Cancer
G Goeckenjan,H. Sitter,Mike Thomas,D Branscheid,Michael Flentje,Frank Griesinger,N Niederle,Martin Stuschke,Torsten Blum,Karl-Matthias Deppermann,Joachim H. Ficker,Lutz Freitag,A. S. Lübbe,Thomas Reinhold,E Späth-Schwalbe,Dieter Ukena,Martin Wickert,M Wolf,S Andreas,T Auberger,R. P. Baum,B Baysal,J Beuth,Heike Bickeböller,A Böcking,R. M. Bohle,I Brüske,Otto Burghuber,N Dickgreber,S Diederich,Hendrik Dienemann,Wilfried Eberhardt,S Eggeling,T Fink,B. Fischer,M Franke,Godehard Friedel,Thomas Gauler,S Gütz,Hubert Hautmann,A Hellmann,Dirk Hellwig,Felix Herth,Claus Peter Heußel,W Hilbe,F Hoffmeyer,Markus Horneber,Rudolf M. Huber,J. Hübner,Hans-Ulrich Kauczor,K Kirchbacher,D Kirsten,Thomas Kraus,S. M. Lang,Uwe M. Martens,A Mohn-Staudner,K.-M. Müller,Jacqueline Müller-Nordhorn,Dennis Nowak,U Ochmann,B. Passlick,Iver Petersen,R. Pirker,B Pokrajac,Martin Reck,S Riha,Christian Rübe,Alexander Schmittel,Nicolas Schönfeld,W Schütte,Monika Serke,Georgios Stamatis,M Steingräber,Martin Steins,Erich Stoelben,L Swoboda,Helmut Teschler,H. W. Tessen,Manuel Weber,A Werner,Heinz-Erich Wichmann,E Irlinger Wimmer,Claudia M. Witt,Heinrich Worth +83 more
Journal ArticleDOI
Negative enrichment by immunomagnetic nanobeads for unbiased characterization of circulating tumor cells from peripheral blood of cancer patients.
Zhian Liu,Alberto Fusi,Eva Klopocki,Alexander Schmittel,Ingeborg Tinhofer,Anika Nonnenmacher,Ulrich Keilholz +6 more
TL;DR: Enriching CTCs using CD45 depletion allowed for detection of epithelial cancer cells not displaying the classical phenotype, which potentially leads to a more accurate estimation of the number of C TCs.