A
Alexander Widiapradja
Researcher at University of Sydney
Publications - 14
Citations - 824
Alexander Widiapradja is an academic researcher from University of Sydney. The author has contributed to research in topics: Cardiac fibrosis & Fibrosis. The author has an hindex of 10, co-authored 12 publications receiving 658 citations. Previous affiliations of Alexander Widiapradja include National University of Singapore & Royal North Shore Hospital.
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Journal ArticleDOI
Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke
Yang-Wei Fann,S-Y Lee,Silvia Manzanero,Sung-Chun Tang,Mathias Gelderblom,Prasad Chunduri,Christian Bernreuther,Markus Glatzel,Yi-Lin Cheng,John Thundyil,Alexander Widiapradja,Ker Zhing Lok,S L Foo,Y-C Wang Wang,Y-I Li,Grant R Drummond,Milan Basta,Tim Magnus,Dong-Gyu Jo,Mark P. Mattson,Christopher G. Sobey,Thiruma V. Arumugam,Thiruma V. Arumugam,Thiruma V. Arumugam +23 more
TL;DR: Evidence is provided that the NLRP1 and NLRP3 inflammasomes have a major role in neuronal cell death and behavioral deficits in stroke, and that IVIg treatment can protect brain cells against ischemic damage, suggesting a potential clinical benefit of therapeutic interventions that targetinflammasome assembly and activity.
Journal ArticleDOI
Intermittent fasting attenuates inflammasome activity in ischemic stroke
David Y. Fann,David Y. Fann,Tomislav Santro,Silvia Manzanero,Alexander Widiapradja,Alexander Widiapradja,Yi-Lin Cheng,Yi-Lin Cheng,Seung Yoon Lee,Prasad Chunduri,Dong-Gyu Jo,Alexis M. Stranahan,Mark P. Mattson,Thiruma V. Arumugam,Thiruma V. Arumugam,Thiruma V. Arumugam +15 more
TL;DR: It is demonstrated that IF can attenuate the inflammatory response and tissue damage following ischemic stroke by a mechanism involving suppression of NLRP1 and NLRP3 inflammasome activity.
Journal ArticleDOI
The Complement C3a Receptor Contributes to Melanoma Tumorigenesis by Inhibiting Neutrophil and CD4+ T Cell Responses.
Jamileh A. Nabizadeh,Helga D. Manthey,Frederik J. Steyn,Weiyu Chen,Alexander Widiapradja,Fazrena Nadia Md Akhir,Glen M. Boyle,Stephen M. Taylor,Trent M. Woodruff,Barbara E. Rolfe +9 more
TL;DR: Therapeutic inhibition of C3aR may be an effective means to trigger an antitumor response in melanoma and other cancers, and it is proposed that C 3aR activation alters the tumor inflammatory milieu, thereby promoting tumor growth.
Journal ArticleDOI
Evidence that the EphA2 receptor exacerbates ischemic brain injury.
John Thundyil,Silvia Manzanero,Dale Pavlovski,Tanya R. Cully,Ker Zhing Lok,Alexander Widiapradja,Prasad Chunduri,Dong-Gyu Jo,Chie Naruse,Masahide Asano,Bradley S. Launikonis,Christopher G. Sobey,Mark G. Coulthard,Mark G. Coulthard,Thiruma V. Arumugam +14 more
TL;DR: The data provide the first evidence that the EphA2 receptor directly contributes to blood-brain barrier damage and neuronal death following ischemic stroke.
Journal ArticleDOI
Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways.
Alexander Widiapradja,Viktor Vegh,Ker Zhing Lok,Silvia Manzanero,John Thundyil,Mathias Gelderblom,Yi-Lin Cheng,Dale Pavlovski,Sung-Chun Tang,Dong-Gyu Jo,Tim Magnus,Sic L. Chan,Christopher G. Sobey,David C. Reutens,Milan Basta,Mark P. Mattson,Thiruma V. Arumugam +16 more
TL;DR: In this article, the effect of intravenous immunoglobulin (IVIg) on downstream signaling pathways that are involved in neuronal cell death in experimental models of stroke and Alzheimer's disease was investigated.