T
Thiruma V. Arumugam
Researcher at La Trobe University
Publications - 205
Citations - 15784
Thiruma V. Arumugam is an academic researcher from La Trobe University. The author has contributed to research in topics: Stroke & Inflammation. The author has an hindex of 61, co-authored 187 publications receiving 12921 citations. Previous affiliations of Thiruma V. Arumugam include Agency for Science, Technology and Research & LSU Health Sciences Center Shreveport.
Papers
More filters
Journal ArticleDOI
Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
Mathias Gelderblom,Frank Leypoldt,Karin Steinbach,Doerthe Behrens,Chi-Un Choe,Dominic A. Siler,Thiruma V. Arumugam,Ellen Orthey,Christian Gerloff,Eva Tolosa,Tim Magnus +10 more
TL;DR: The peculiar activation pattern and massive increase of antigen-presenting cells in temporal conjunction with regulatory cells might provide additional insight into poststroke immune regulation.
Journal ArticleDOI
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
Sung-Chun Tang,Thiruma V. Arumugam,Thiruma V. Arumugam,Xiangru Xu,Aiwu Cheng,Mohamed R. Mughal,Dong-Gyu Jo,Dong-Gyu Jo,Justin D. Lathia,Dominic A. Siler,Srinivasulu Chigurupati,Xin Ouyang,Tim Magnus,Tim Magnus,Simonetta Camandola,Mark P. Mattson,Mark P. Mattson +16 more
TL;DR: It is reported that neurons express several TLRs, and that the levels of TLR2 and -4 are increased in neurons in response to IFN-γ stimulation and energy deprivation, establishing a proapoptotic signaling pathway for TLR1 and -3 in neurons that may render them vulnerable to ischemic death.
Journal ArticleDOI
Role of T lymphocytes and interferon-gamma in ischemic stroke.
TL;DR: Findings indicate that CD4+ and CD8+ T lymphocytes, but not B lymphocyte, contribute to the inflammatory and thrombogenic responses, brain injury, and neurological deficit associated with experimental stroke.
Journal ArticleDOI
Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.
TL;DR: An overview of the cellular and molecular biology of brain aging, how those processes interface with disease-specific neurodegenerative pathways, and how metabolic states influence brain health is provided.
Journal ArticleDOI
Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons
Alexis M. Stranahan,Thiruma V. Arumugam,Thiruma V. Arumugam,Roy G. Cutler,Kim Lee,Josephine M. Egan,Mark P. Mattson +6 more
TL;DR: It is demonstrated that, in both insulin-deficient rats and insulin-resistant mice, diabetes impairs hippocampus-dependent memory, perforant path synaptic plasticity and adult neurogenesis, and the adrenal steroid corticosterone contributes to these adverse effects.