S
Sung-Chun Tang
Researcher at National Taiwan University
Publications - 232
Citations - 7394
Sung-Chun Tang is an academic researcher from National Taiwan University. The author has contributed to research in topics: Stroke & Medicine. The author has an hindex of 37, co-authored 189 publications receiving 6191 citations. Previous affiliations of Sung-Chun Tang include Electronics Research Center & National Institutes of Health.
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Journal ArticleDOI
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
Sung-Chun Tang,Thiruma V. Arumugam,Thiruma V. Arumugam,Xiangru Xu,Aiwu Cheng,Mohamed R. Mughal,Dong-Gyu Jo,Dong-Gyu Jo,Justin D. Lathia,Dominic A. Siler,Srinivasulu Chigurupati,Xin Ouyang,Tim Magnus,Tim Magnus,Simonetta Camandola,Mark P. Mattson,Mark P. Mattson +16 more
TL;DR: It is reported that neurons express several TLRs, and that the levels of TLR2 and -4 are increased in neurons in response to IFN-γ stimulation and energy deprivation, establishing a proapoptotic signaling pathway for TLR1 and -3 in neurons that may render them vulnerable to ischemic death.
Journal ArticleDOI
Pathophysiology, treatment, and animal and cellular models of human ischemic stroke
Trent M. Woodruff,John Thundyil,Sung-Chun Tang,Christopher G. Sobey,Stephen M. Taylor,Thiruma V. Arumugam +5 more
TL;DR: This review explores the etiology and pathogenesis of ischemic stroke, and provides a general model of such, and explores new and emerging approaches for the prevention and treatment of stroke.
Journal ArticleDOI
Toll-Like Receptors in Neurodegeneration
Eitan Okun,Kathleen J. Griffioen,Justin D. Lathia,Justin D. Lathia,Sung-Chun Tang,Mark P. Mattson,Thiruma V. Arumugam +6 more
TL;DR: A better understanding of the molecular and cellular biology of TLRs in the normal and diseased nervous system, may lead to novel approaches for preventing neuronal degeneration and promoting recovery of function in an array of neurodegenerative conditions.
Journal ArticleDOI
Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke
Yang-Wei Fann,S-Y Lee,Silvia Manzanero,Sung-Chun Tang,Mathias Gelderblom,Prasad Chunduri,Christian Bernreuther,Markus Glatzel,Yi-Lin Cheng,John Thundyil,Alexander Widiapradja,Ker Zhing Lok,S L Foo,Y-C Wang Wang,Y-I Li,Grant R Drummond,Milan Basta,Tim Magnus,Dong-Gyu Jo,Mark P. Mattson,Christopher G. Sobey,Thiruma V. Arumugam,Thiruma V. Arumugam,Thiruma V. Arumugam +23 more
TL;DR: Evidence is provided that the NLRP1 and NLRP3 inflammasomes have a major role in neuronal cell death and behavioral deficits in stroke, and that IVIg treatment can protect brain cells against ischemic damage, suggesting a potential clinical benefit of therapeutic interventions that targetinflammasome assembly and activity.
Journal ArticleDOI
Toll-like receptors in ischemia-reperfusion injury.
Thiruma V. Arumugam,Eitan Okun,Sung-Chun Tang,John Thundyil,Stephen M. Taylor,Trent M. Woodruff +5 more
TL;DR: The contribution of TLR activation in hepatic, renal, cerebral, intestinal, and myocardial I/R injuries is discussed and the development of specific TLR-targeted therapeutics to treat these conditions is discussed.