A
Alexandra Giatromanolaki
Researcher at Democritus University of Thrace
Publications - 360
Citations - 26647
Alexandra Giatromanolaki is an academic researcher from Democritus University of Thrace. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 66, co-authored 340 publications receiving 22956 citations. Previous affiliations of Alexandra Giatromanolaki include John Radcliffe Hospital.
Papers
More filters
Journal ArticleDOI
Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression.
Alexandra Giatromanolaki,Michael I. Koukourakis,Efthimios Sivridis,Kevin C. Gatter,Adrian L. Harris,Alison H. Banham +5 more
TL;DR: Evidence on pathways to be investigated to elucidate the interplay between FOXP1, ER-α and HIF-1α in hormone dependent cancers is provided and survival analysis did not reveal significant differences among patients grouped by FoxP1 expression.
Journal ArticleDOI
Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer.
Michael I. Koukourakis,Alexandra Giatromanolaki,Efthimios Sivridis,Jaromir Pastorek,Ilias Karapantzos,Kevin C. Gatter,Adrian L. Harris +6 more
TL;DR: Targeting the hypoxia-regulated molecular cascade emerged as a complementary radiosensitization strategy for a large group of patients with hypoxic tumors, who are unlikely to benefit from conventional approaches aiming to improve intratumoral oxygen delivery through anemia correction.
Journal ArticleDOI
Autophagy patterns and prognosis in uveal melanomas.
Alexandra Giatromanolaki,Georgios Charitoudis,Nikolaos E. Bechrakis,Vassilios Kozobolis,Michael I. Koukourakis,Michael H. Foerster,Efthimios Sivridis +6 more
TL;DR: It is concluded that autophagy is commonly upregulated in uveal melanomas, and may be associated with hypoxia and intense pigmentation, and there is a strong association between extensive BECN1 overexpression and early metastases/poor prognosis, and between underexpression of this protein and late metastases and better prognosis.
Journal ArticleDOI
Fever-range hyperthermia vs. hypothermia effect on cancer cell viability, proliferation and HSP90 expression
Dimitra Kalamida,Ilias V. Karagounis,Achilleas Mitrakas,Sofia Kalamida,Alexandra Giatromanolaki,Michael I. Koukourakis +5 more
TL;DR: Of interest, mild hypothermia had a universal suppressing effect on cancer cell proliferation, further supporting the radio-sensitization hypothesis through reduction of oxygen and metabolic demands.
Journal ArticleDOI
The pathology of tumor stromatogenesis.
TL;DR: Cancer cells and neostroma should not be seen as a mixture of heterogeneous uncoordinated cells but rather as a unified morphologic and metabolic domain with a harmonious collaboration between aerobic (myofibroblasts, endothelial cells) and anaerobic compartments (cancer cells).