A
Alexandra Giatromanolaki
Researcher at Democritus University of Thrace
Publications - 360
Citations - 26647
Alexandra Giatromanolaki is an academic researcher from Democritus University of Thrace. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 66, co-authored 340 publications receiving 22956 citations. Previous affiliations of Alexandra Giatromanolaki include John Radcliffe Hospital.
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Journal Article
Bax protein expression in colorectal cancer: association with p53, bcl-2 and patterns of relapse.
Alexandra Giatromanolaki,Efthimios Sivridis,George P. Stathopoulos,George Fountzilas,Haralambos P. Kalofonos,Athanasios Tsamandas,Eleni Vrettou,Chrisoula D. Scopa,Alexandros Polychronidis,Konstantinos Simopoulos,Michael I. Koukourakis +10 more
TL;DR: The development of novel monoclonal antibodies recognising specifically the mutated versus the wild type form of proteins would apparently improve the prognostic and predictive value of the immunohistochemically detected apoptotic proteins.
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Autophagy and Bcl‐2/BNIP3 death regulatory pathway in non‐small cell lung carcinomas
Georgia Karpathiou,Efthimios Sivridis,Michael I. Koukourakis,Dimitrios Mikroulis,Demosthenes Bouros,Marios Froudarakis,George Bougioukas,Efstratios Maltezos,Alexandra Giatromanolaki +8 more
TL;DR: The accelerated autophagic status in NSCLC is unrelated to Beclin 1 and BNIP3 expression, but does show significant association with Bcl‐2 reactivity, and important correlations between glucolysis and autophagy are shown, guiding new pathways in future lung carcinoma research.
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Neo-angiogenesis in locally advanced squamous cell head and neck cancer correlates with thymidine phosphorylase expression and p53 nuclear oncoprotein accumulation.
Alexandra Giatromanolaki,George Fountzilas,Michael I. Koukourakis,Petroula Arapandoni,Varvara Theologi,Stylianos Kakolyris,V. Georgoulias,Adrian L. Harris,Kevin C. Gatter +8 more
TL;DR: It is concluded that intense neo-angiogene-sis in locally advanced squamous cell head neck cancer is a frequent event, which is associated with nuclear p53 accumulation and thymidine phosphorylase overexpression.
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Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway
Alexandra Giatromanolaki,Michael I. Koukourakis,Francesco Pezzella,Helen Turley,Efthimios Sivridis,Demosthenes Bouros,George Bougioukas,Adrian L. Harris,Kevin C. Gatter +8 more
TL;DR: The oxygen sensitive prolyl-hydroxylase domain enzymes (PHDs) and the asparagines hydroxylases (FIH, factor inhibiting HIF) regulate the transcriptional activity of HIFs.
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Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1α
Michael I. Koukourakis,Alexandra Giatromanolaki,Wen Chong,C. Simopoulos,Alexandros Polychronidis,Efthimios Sivridis,Adrian L. Harris +6 more
TL;DR: Since it is doubtful whether dephosphorylation of amifostine to the active metabolite WR-1065 occurs within tumoral tissues (an acidic environment that lacks vascular alkaline phosphatase activity), intracellular hypoxia and upregulation of HIF1α represents an additional, normal tissue-specific, am ifostine cytoprotective pathway.