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Alexandra Groom
Researcher at Newcastle University
Publications - 7
Citations - 558
Alexandra Groom is an academic researcher from Newcastle University. The author has contributed to research in topics: DNA methylation & Regulation of gene expression. The author has an hindex of 7, co-authored 7 publications receiving 525 citations. Previous affiliations of Alexandra Groom include University of Bristol & Centre for Life.
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Journal ArticleDOI
DNA Methylation Patterns in Cord Blood DNA and Body Size in Childhood
Caroline L Relton,Alexandra Groom,Beate St Pourcain,Adrian Sayers,Daniel Swan,Nicholas D. Embleton,Nicholas D. Embleton,Mark S. Pearce,Susan M. Ring,Kate Northstone,Jon H Tobias,Joseph Trakalo,Andy R Ness,Seif O. Shaheen,George Davey Smith +14 more
TL;DR: DNA methylation patterns in cord blood show some association with altered gene expression, body size and composition in childhood, and despite suggestion of a mechanistic epigenetic link between in utero life and later phenotype, further investigation is required to establish causality.
Journal ArticleDOI
Genetic and Non-Genetic Influences during Pregnancy on Infant Global and Site Specific DNA Methylation: Role for Folate Gene Variants and Vitamin B12
Jill A. McKay,Alexandra Groom,Catherine Potter,Lisa J. Coneyworth,Dianne Ford,John C. Mathers,Caroline L Relton +6 more
TL;DR: The hypothesis that both environmental and genetic factors involved in one-carbon metabolism influence DNA methylation in infants is supported, as the findings highlight the importance of vitamin B12 status, infant MTRR genotype and maternal MTHFR genotype, all of which may influence the supply of methyl groups forDNA methylation.
Journal ArticleDOI
People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population
Bruce Winney,Abdelhamid Boumertit,Tammy Day,Dan Davison,Chikodi Echeta,Irina Evseeva,Katarzyna Hutnik,Stephen Leslie,Kristin K. Nicodemus,Ellen C. Røyrvik,Susan Tonks,Xiaofeng Yang,James Cheshire,Paul A. Longley,Pablo Mateos,Alexandra Groom,Caroline L Relton,D. Tim Bishop,Kathryn Black,Emma Northwood,Louise Parkinson,Timothy M. Frayling,Anna M. Steele,Julian R. Sampson,Turi E. King,Ronald A. Dixon,Derek Middleton,Barbara A. Jennings,Rory Bowden,Peter Donnelly,Walter F. Bodmer +30 more
TL;DR: The collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK-control population that can be used as a resource by the research community, as well as providing a fine-scale genetic information on the British population.
Journal ArticleDOI
DNA methylation signatures in cord blood associated with maternal gestational weight gain: results from the ALSPAC cohort
TL;DR: Greater GWG in early pregnancy was associated with increased methylation at CpG sites at MMP7, KCNK4, TRPM5 and NFKB1 genes in offspring cord blood DNA, and the potential functional relevancy of the four identified loci is advocated.
Journal ArticleDOI
Postnatal Growth and DNA Methylation Are Associated With Differential Gene Expression of the TACSTD2 Gene and Childhood Fat Mass
Alexandra Groom,Catherine Potter,Daniel Swan,Ghazaleh Fatemifar,David M. Evans,Susan M. Ring,Valérie Turcot,Mark S. Pearce,Nicholas D. Embleton,George Davey Smith,John C. Mathers,Caroline L Relton +11 more
TL;DR: The lack of association between fat mass and a methylation proxy SNP suggests that reverse causation or confounding may explain the initial association betweenFat mass and gene regulation and noncausal methylation patterns may still be useful predictors of later adiposity.