J
Jon H Tobias
Researcher at University of Bristol
Publications - 64
Citations - 3189
Jon H Tobias is an academic researcher from University of Bristol. The author has contributed to research in topics: Bone density & Population. The author has an hindex of 23, co-authored 64 publications receiving 2714 citations. Previous affiliations of Jon H Tobias include St George's Hospital & University of Queensland.
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Journal ArticleDOI
Using multiple genetic variants as instrumental variables for modifiable risk factors
Tom Palmer,Debbie A Lawlor,Roger M. Harbord,Nuala A. Sheehan,Jon H Tobias,Nicholas J. Timpson,George Davey Smith,Jonathan A C Sterne +7 more
TL;DR: Under the correct conditions, multiple instrument analyses are a promising approach for Mendelian randomisation studies, and further research is required into multiple imputation methods to address missing data issues in IV estimation.
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Association Between Bone Mass and Fractures in Children: A Prospective Cohort Study
TL;DR: This is the first prospective cohort study of the association between bone mass and fracture risk in childhood and results showed an 89% increased risk of fracture per SD decrease in size‐adjusted BMC.
Journal ArticleDOI
WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk
Hou-Feng Zheng,Jon H Tobias,Emma L. Duncan,Emma L. Duncan,David M. Evans,Joel Eriksson,Lavinia Paternoster,Laura M. Yerges-Armstrong,Terho Lehtimäki,Ulrica Bergström,Mika Kähönen,Paul Leo,Olli T. Raitakari,Marika Laaksonen,Geoffrey C. Nicholson,Jorma Viikari,Martin Ladouceur,Leo-Pekka Lyytikäinen,Carolina Medina-Gomez,Fernando Rivadeneira,Richard L. Prince,Richard L. Prince,Harri Sievänen,William D. Leslie,Dan Mellström,John A. Eisman,Sofia Movérare-Skrtic,David Goltzman,David A. Hanley,Graeme Jones,Beate St Pourcain,Yongjun Xiao,Nicholas J. Timpson,George Davey Smith,Ian R. Reid,Susan M. Ring,Philip N. Sambrook,Magnus Karlsson,Elaine M. Dennison,John P. Kemp,Patrick Danoy,Adrian Sayers,Scott Wilson,Scott Wilson,Scott Wilson,Maria Nethander,Eugene V. McCloskey,Liesbeth Vandenput,Richard Eastell,Jeff Liu,Tim D. Spector,Braxton D. Mitchell,Elizabeth A. Streeten,Elizabeth A. Streeten,Robert Brommage,Ulrika Pettersson-Kymmer,Matthew A. Brown,Claes Ohlsson,J. Brent Richards,J. Brent Richards,J. Brent Richards,Mattias Lorentzon +61 more
TL;DR: In this article, the authors identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts consisting 5,672 individuals.
Journal ArticleDOI
Intervertebral disc degeneration can lead to "stress-shielding" of the anterior vertebral body: a cause of osteoporotic vertebral fracture?
TL;DR: Severe disc degeneration causes the anterior vertebral body to be stress-shielded during the usual erect posture, and yet severely loaded whenever the spine is flexed, which could help to explain why this region is frequently the site of osteoporotic fracture, and why forward bending movements often precipitate the injury.
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Habitual levels of physical activity influence bone mass in 11-year-old children from the United Kingdom: Findings from a large population-based cohort
TL;DR: Physical activity was positively related to both BMD and bone size in fully adjusted models, however, further exploration revealed that this effect on bone size was modified by fat mass.