A
Alexandra M. Lewis
Researcher at University of Washington
Publications - 3
Citations - 303
Alexandra M. Lewis is an academic researcher from University of Washington. The author has contributed to research in topics: Genome & Human genome. The author has an hindex of 3, co-authored 3 publications receiving 85 citations.
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The structure, function and evolution of a complete human chromosome 8
Glennis A. Logsdon,Mitchell R. Vollger,PingHsun Hsieh,Yafei Mao,Mikhail Liskovykh,Sergey Koren,Sergey Nurk,Ludovica Mercuri,Philip C. Dishuck,Arang Rhie,Leonardo G. de Lima,Tatiana Dvorkina,David Porubsky,William T. Harvey,Alla Mikheenko,Andrey Bzikadze,Milinn Kremitzki,Tina A. Graves-Lindsay,Chirag Jain,Kendra Hoekzema,Shwetha C. Murali,Katherine M. Munson,Carl Baker,Melanie Sorensen,Alexandra M. Lewis,Urvashi Surti,Jennifer L. Gerton,Vladimir Larionov,Mario Ventura,Karen H. Miga,Adam M. Phillippy,Evan E. Eichler +31 more
TL;DR: In this article, the authors used complementary long-read sequencing technologies to complete the linear assembly of human chromosome 8, including a 2.08-Mb centromeric α-satellite array, a 644-kb copy number polymorphism in the β-defensin gene cluster that is important for disease risk, and an 863-kb variable number tandem repeat at chromosome 8q21.2 that can function as a neocentromere.
Posted ContentDOI
The structure, function, and evolution of a complete human chromosome 8
Glennis A. Logsdon,Mitchell R. Vollger,PingHsun Hsieh,Yafei Mao,Mikhail Liskovykh,Sergey Koren,Sergey Nurk,Ludovica Mercuri,Philip C. Dishuck,Arang Rhie,Leonardo G. de Lima,David Porubsky,Andrey Bzikadze,Milinn Kremitzki,Tina A. Graves-Lindsay,Chirag Jain,Kendra Hoekzema,Shwetha C. Murali,Shwetha C. Murali,Katherine M. Munson,Carl Baker,Melanie Sorensen,Alexandra M. Lewis,Urvashi Surti,Jennifer L. Gerton,Vladimir Larionov,Mario Ventura,Karen H. Miga,Adam M. Phillippy,Evan E. Eichler,Evan E. Eichler +30 more
TL;DR: Comparative and phylogenetic analyses show that the higher-order α-satellite structure evolved specifically in the great ape ancestor, and the centromeric region evolved with a layered symmetry, with more ancient higher- order repeats located at the periphery adjacent to monomeric α-Satellites.
Posted ContentDOI
Segmental duplications and their variation in a complete human genome
Mitchell R. Vollger,Guitart X,Philip C. Dishuck,Ludovica Mercuri,William T. Harvey,Ariel Gershman,Mark Diekhans,Arvis Sulovari,Katherine M. Munson,Alexandra M. Lewis,Kendra Hoekzema,David Porubsky,Ruiyang Li,Sergey Nurk,Sergey Koren,Karen H. Miga,Adam M. Phillippy,Winston Timp,Mario Ventura,Evan E. Eichler,Evan E. Eichler +20 more
TL;DR: Based on a complete telomere-to-telomere human genome (T2T-CHM13), this paper presented the first comprehensive view of human segmental duplications organization.