K
Kendra Hoekzema
Researcher at University of Washington
Publications - 59
Citations - 3539
Kendra Hoekzema is an academic researcher from University of Washington. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 20, co-authored 46 publications receiving 2346 citations. Previous affiliations of Kendra Hoekzema include Oregon State University & Huazhong University of Science and Technology.
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Journal ArticleDOI
Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases
Holly A.F. Stessman,Bo Xiong,Bo Xiong,Bradley P. Coe,Tianyun Wang,Kendra Hoekzema,Kendra Hoekzema,Michaela Fenckova,Malin Kvarnung,Jennifer Gerdts,Sandy Trinh,Nele Cosemans,Laura Vives,Janice Lin,Tychele N. Turner,Gijs W. E. Santen,Claudia A. L. Ruivenkamp,Marjolein Kriek,Arie van Haeringen,Emmelien Aten,Kathryn Friend,Kathryn Friend,Jan Liebelt,Christopher Barnett,Eric Haan,Eric Haan,Marie Shaw,Jozef Gecz,Jozef Gecz,Jozef Gecz,Britt-Marie Anderlid,Ann Nordgren,Anna Lindstrand,Charles E. Schwartz,R. Frank Kooy,Geert Vandeweyer,Céline Helsmoortel,Corrado Romano,Antonino Alberti,Mirella Vinci,Emanuela Avola,Stefania Giusto,Eric Courchesne,Tiziano Pramparo,Karen Pierce,Srinivasa Nalabolu,David G. Amaral,Ingrid E. Scheffer,Ingrid E. Scheffer,Martin B. Delatycki,Paul J. Lockhart,Fereydoun Hormozdiari,Benjamin Harich,Anna Castells-Nobau,Kun Xia,Hilde Peeters,Magnus Nordenskjöld,Annette Schenck,Raphael Bernier,Evan E. Eichler,Evan E. Eichler +60 more
TL;DR: Twenty-five genes showing a bias for autism versus intellectual disability and a network associated with high-functioning autism are highlighted, and clinical follow-up for NAA15, KMT5B, and ASH1L highlighted new syndromic and nonsyndromic forms of disease.
Journal ArticleDOI
Discovery and genotyping of structural variation from long-read haploid genome sequence data
John Huddleston,Mark Chaisson,Karyn Meltz Steinberg,Wes Warren,Kendra Hoekzema,David Gordon,Tina A. Graves-Lindsay,Katherine M. Munson,Zev N. Kronenberg,Laura Vives,Paul Peluso,Matthew Boitano,Chen-Shin Chin,Jonas Korlach,Richard K. Wilson,Evan E. Eichler +15 more
TL;DR: Interestingly, when the authors repeat SV detection on a pseudodiploid genome constructed in silico by merging the two haploids, it is found that ∼59% of the heterozygous SVs are no longer detected by SMRT-SV, indicating that haploid resolution of long-read sequencing data will significantly increase sensitivity of SV detection.
Journal ArticleDOI
High-resolution comparative analysis of great ape genomes
Zev N. Kronenberg,Ian T. Fiddes,David Gordon,Shwetha C. Murali,Stuart Cantsilieris,Olivia S. Meyerson,Jason G. Underwood,Jason G. Underwood,Bradley J. Nelson,Mark Chaisson,Mark Chaisson,Max L. Dougherty,Katherine M. Munson,Alex Hastie,Mark Diekhans,Fereydoun Hormozdiari,Nicola Lorusso,Kendra Hoekzema,Ruolan Qiu,Karen Clark,Archana Raja,Anne Marie E. Welch,Melanie Sorensen,Carl Baker,Robert S. Fulton,Joel Armstrong,Tina A. Graves-Lindsay,Ahmet M. Denli,Emma R. Hoppe,PingHsun Hsieh,Christopher M. Hill,Andy Wing Chun Pang,Joyce V. Lee,Ernest T. Lam,Susan K. Dutcher,Fred H. Gage,Wesley C. Warren,Jay Shendure,David Haussler,Valerie A. Schneider,Han Cao,Mario Ventura,Richard K. Wilson,Benedict Paten,Alex A. Pollen,Evan E. Eichler +45 more
TL;DR: The improved ape genome assemblies provide the most comprehensive view to date of intermediate-size structural variation and highlight several dozen genes associated withStructural variation and brain-expression differences between humans and chimpanzees.
Journal ArticleDOI
Genomic Patterns of De Novo Mutation in Simplex Autism
Tychele N. Turner,Bradley P. Coe,Diane E. Dickel,Kendra Hoekzema,Bradley J. Nelson,Michael C. Zody,Zev N. Kronenberg,Fereydoun Hormozdiari,Archana Raja,Len A. Pennacchio,Robert B. Darnell,Evan E. Eichler +11 more
TL;DR: Patients are more likely to carry multiple coding and noncoding DNMs in different genes, which are enriched for expression in striatal neurons, suggesting a path forward for genetically characterizing more complex cases of autism.
Journal ArticleDOI
De novo genic mutations among a Chinese autism spectrum disorder cohort
Tianyun Wang,Hui Guo,Bo Xiong,Holly A.F. Stessman,Huidan Wu,Bradley P. Coe,Tychele N. Turner,Yanling Liu,Wenjing Zhao,Kendra Hoekzema,Laura Vives,Lu Xia,Meina Tang,Jianjun Ou,Biyuan Chen,Yidong Shen,Guanglei Xun,Min Long,Janice Lin,Zev N. Kronenberg,Yu Peng,Ting Bai,Honghui Li,Xiaoyan Ke,Zhengmao Hu,Jingping Zhao,Xiaobing Zou,Kun Xia,Evan E. Eichler +28 more
TL;DR: Phenotypic follow-up confirms potential subtypes and highlights how large global cohorts might be leveraged to prove the pathogenic significance of individually rare mutations.