A
Alexandre Leitão
Researcher at University of Lisbon
Publications - 70
Citations - 1874
Alexandre Leitão is an academic researcher from University of Lisbon. The author has contributed to research in topics: Virus & African swine fever virus. The author has an hindex of 25, co-authored 61 publications receiving 1493 citations. Previous affiliations of Alexandre Leitão include Indian Institute of Chemical Technology & Technical University of Lisbon.
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The non-haemadsorbing African swine fever virus isolate ASFV/NH/P68 provides a model for defining the protective anti-virus immune response.
Alexandre Leitão,Clara Cartaxeiro,Ricardo Coelho,Benedita Cruz,R. M. E. Parkhouse,Fernando C. Portugal,José D. Vigário,Carlos Martins +7 more
TL;DR: This infection model may provide new insights on mechanisms of protective immunity to ASFV and lymphoproliferative responses to the mitogens concanavalin A, phytohaemagglutinin and pokeweed mitogen were not depressed in either of the two clinically defined groups of pigs.
Journal ArticleDOI
Related strains of African swine fever virus with different virulence: genome comparison and analysis
Raquel Portugal,João Coelho,Dirk Höper,Nicole S. Little,Chad Smithson,Chris Upton,Carlos Martins,Alexandre Leitão,Günther M. Keil +8 more
TL;DR: A relatively lower genomic identity exists between L60 and NHV, both isolated in a similar geographical location 8 years apart, than with other European and west African strains isolated subsequently and in more distant locations, contributing to a better understanding of the evolution of ASFV.
Journal ArticleDOI
Isolation of Besnoitia besnoiti from infected cattle in Portugal.
Helder Cortes,Y. Reis,Helga Waap,R. Vidal,Helena Soares,I. Marques,I. Pereira da Fonseca,Isabel Fazendeiro,Maurício Lamano Ferreira,V. Caeiro,V. Shkap,Andrew Hemphill,Alexandre Leitão +12 more
TL;DR: The identification of large cysts in the skin of a cow and a bull in Portugal, which presented loss of hair and enlargement and pachydermis all over the body, is reported on.
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Systematic analysis of longitudinal serological responses of pigs infected experimentally with African swine fever virus.
TL;DR: One exception was the antibody response to the A104R/histone-like protein, which was higher in asymptomatic than in chronically infected pigs, suggesting that antibodies against this protein might be an indicator of an effective immune response or that this response is somehow involved in protection.
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A review on bovine besnoitiosis: a disease with economic impact in herd health management, caused by Besnoitia besnoiti (Franco and Borges, ).
TL;DR: There is still no effective pharmaceutical compound available for the treatment of besnoitiosis in cattle, and progress in the identification of novel targets for intervention through pharmacological or immunological means is hampered by the lack of molecular data on the genomic and transcriptomic level.