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Alexey V. Glukhov
Researcher at University of Wisconsin-Madison
Publications - 79
Citations - 2701
Alexey V. Glukhov is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Sinoatrial node & Medicine. The author has an hindex of 25, co-authored 71 publications receiving 2298 citations. Previous affiliations of Alexey V. Glukhov include The Ohio State University Wexner Medical Center & Imperial College London.
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Journal ArticleDOI
Transmural Dispersion of Repolarization in Failing and Nonfailing Human Ventricle
Alexey V. Glukhov,Vadim V. Fedorov,Qing Lou,Vinod K Ravikumar,Paul W. Kalish,Richard B. Schuessler,Nader Moazami,Igor R. Efimov +7 more
TL;DR: This work presents for the first time direct experimental evidence of a transmural APD gradient in the human heart and results in the heterogeneous prolongation of APD, which significantly reduces the transmural and local APD gradients.
Journal ArticleDOI
Roles of adrenergic and cholinergic stimulation in spontaneous atrial fibrillation in dogs
Oleg F. Sharifov,Vadim V. Fedorov,G. G. Beloshapko,Alexey V. Glukhov,Anna V. Yushmanova,Leonid V. Rosenshtraukh +5 more
TL;DR: Data indicate that although both autonomic systems play a role in AF, cholinergic stimulation is likely the main factor for spontaneous AF initiation in this animal model.
Journal ArticleDOI
Oxidized CaMKII causes cardiac sinus node dysfunction in mice
Paari Dominic Swaminathan,Anil Purohit,Siddarth Soni,Niels Voigt,Niels Voigt,Madhu V. Singh,Alexey V. Glukhov,Zhan Gao,B. Julie He,Elizabeth D. Luczak,Mei Ling A. Joiner,William Kutschke,Jinying Yang,J. Kevin Donahue,Robert M. Weiss,Isabella M. Grumbach,Masahiro Ogawa,Masahiro Ogawa,Peng Sheng Chen,Igor R. Efimov,Dobromir Dobrev,Dobromir Dobrev,Peter J. Mohler,Thomas J. Hund,Mark E. Anderson +24 more
TL;DR: A computational model of the sinoatrial node showed that a loss of SAN cells below a critical threshold caused SND by preventing normal impulse formation and propagation, and suggested that targeted CaMKII inhibition may be useful for preventing SND in high-risk patients.
Journal ArticleDOI
Conduction Remodeling in Human End-Stage Nonischemic Left Ventricular Cardiomyopathy
Alexey V. Glukhov,Vadim V. Fedorov,Paul W. Kalish,Vinod K Ravikumar,Qing Lou,Deborah Janks,Richard B. Schuessler,Nader Moazami,Igor R. Efimov +8 more
TL;DR: Conduction disorder resulting from the anisotropic downregulation of CX43 expression, the reduction of Cx43 phosphorylation, and increased fibrosis is likely to be a critical component of arrhythmogenic substrate in patients with nonischemic cardiomyopathy.
Journal ArticleDOI
Transmural Heterogeneity and Remodeling of Ventricular Excitation-Contraction Coupling in Human Heart Failure
TL;DR: For the first time, direct experimental evidence of transmural heterogeneity of excitation-contraction coupling and calcium handling in human hearts is presented and it is shown that end-stage heart failure is associated with the heterogeneous remodeling of excitement-contracted coupling andcium handling.