S
Siddarth Soni
Researcher at Utrecht University
Publications - 7
Citations - 314
Siddarth Soni is an academic researcher from Utrecht University. The author has contributed to research in topics: Heart failure & Protein kinase A. The author has an hindex of 5, co-authored 7 publications receiving 271 citations. Previous affiliations of Siddarth Soni include University Medical Center Utrecht.
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Journal ArticleDOI
Oxidized CaMKII causes cardiac sinus node dysfunction in mice
Paari Dominic Swaminathan,Anil Purohit,Siddarth Soni,Niels Voigt,Niels Voigt,Madhu V. Singh,Alexey V. Glukhov,Zhan Gao,B. Julie He,Elizabeth D. Luczak,Mei Ling A. Joiner,William Kutschke,Jinying Yang,J. Kevin Donahue,Robert M. Weiss,Isabella M. Grumbach,Masahiro Ogawa,Masahiro Ogawa,Peng Sheng Chen,Igor R. Efimov,Dobromir Dobrev,Dobromir Dobrev,Peter J. Mohler,Thomas J. Hund,Mark E. Anderson +24 more
TL;DR: A computational model of the sinoatrial node showed that a loss of SAN cells below a critical threshold caused SND by preventing normal impulse formation and propagation, and suggested that targeted CaMKII inhibition may be useful for preventing SND in high-risk patients.
Journal ArticleDOI
Reorganized PKA-AKAP associations in the failing human heart
Thin-Thin Aye,Siddarth Soni,Siddarth Soni,Toon A.B. van Veen,Marcel A.G. van der Heyden,Salvatore Cappadona,András Varró,Roel A. de Weger,Nicolaas de Jonge,Marc A. Vos,Albert J. R. Heck,Arjen Scholten +11 more
TL;DR: It is revealed that the characterization of large-scale re-arrangements of signaling scaffolds induced by heart failure can serve as a novel concept to identify more specific therapeutic targets, validating that this dataset may provide a resource for several novel, more specific, treatment options.
Journal ArticleDOI
A Proteomics Approach to Identify New Putative Cardiac Intercalated Disk Proteins
Siddarth Soni,Siddarth Soni,Antonia J.A. Raaijmakers,Linsey M. Raaijmakers,J. Mirjam A. Damen,Leonie van Stuijvenberg,Marc A. Vos,Albert J. R. Heck,Toon A.B. van Veen,Arjen Scholten +9 more
TL;DR: A combination of general membrane enrichment, in-depth quantitative proteomics and an intracellular location driven bioinformatics approach is used to discover new putative ID proteins in rat ventricular tissue.
Journal ArticleDOI
Anchored protein kinase A signalling in cardiac cellular electrophysiology
TL;DR: The role of AKAP‐associated protein complexes in acute and chronic cardiac modulation is discussed by dissecting their role in altering the activity of different ion channels, which underlie cardiac action potential (AP) generation.
Journal ArticleDOI
Neuronal Nitric Oxide Synthase-Dependent Amelioration of Diastolic Dysfunction in Rats with Chronic Renocardiac Syndrome
Lennart G. Bongartz,Siddarth Soni,Maarten-Jan M. Cramer,Paul Steendijk,Carlo A. J. M. Gaillard,Marianne C. Verhaar,Pieter A. Doevendans,Toon A.B. van Veen,Jaap A. Joles,Branko Braam +9 more
TL;DR: In this model of CRCS, blockade of nNOS further worsens diastolic dysfunction and L-VNIO does not influence inherent contractility and the response to dobu stress.