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Thomas J. Hund
Researcher at Ohio State University
Publications - 166
Citations - 6346
Thomas J. Hund is an academic researcher from Ohio State University. The author has contributed to research in topics: Ca2+/calmodulin-dependent protein kinase & Ankyrin. The author has an hindex of 40, co-authored 146 publications receiving 5336 citations. Previous affiliations of Thomas J. Hund include The Ohio State University Wexner Medical Center & Roy J. and Lucille A. Carver College of Medicine.
Papers
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Journal ArticleDOI
Rate Dependence and Regulation of Action Potential and Calcium Transient in a Canine Cardiac Ventricular Cell Model
Thomas J. Hund,Yoram Rudy +1 more
TL;DR: The model of CaMKII regulation may serve as a paradigm for modeling effects of other regulatory pathways on cell function, and is an important determinant of the rate dependence of CaT but not of APD, which depends on ion-channel kinetics.
Journal ArticleDOI
Calmodulin-Dependent Protein Kinase II: Linking Heart Failure and Arrhythmias
TL;DR: The molecular physiology of CaMKII is reviewed and actions at key cellular targets and results of animal models of myocardial hypertrophy, dysfunction, and arrhythmias are discussed that suggestCaMKII inhibition may benefit myocardian function while reducing arrh rhythmias.
Journal ArticleDOI
A βIV-spectrin/CaMKII signaling complex is essential for membrane excitability in mice
Thomas J. Hund,Olha M. Koval,Jingdong Li,Patrick J. Wright,Lan Qian,Jedidiah S. Snyder,Hjalti Gudmundsson,Crystal F. Kline,Nathan Paul Davidson,Natalia Cardona,Matthew N. Rasband,Mark E. Anderson,Peter J. Mohler +12 more
TL;DR: In this paper, the authors identified β(IV)-spectrin as a multifunctional regulatory platform for voltage-gated Na(+) channels in mice, and found that β(4)-Spectrin targeted critical structural and regulatory proteins to excitable membranes in the heart and brain.
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The N 6 -Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy.
Lisa E. Dorn,Lior Lasman,Jing Chen,Xianyao Xu,Thomas J. Hund,Mario Medvedovic,Jacob H. Hanna,Jop H. van Berlo,Federica Accornero +8 more
TL;DR: In this paper, the role of m6A mRNA methylation in the heart is not known, but it is known that m6-Methyladenosine (m6A) methylation is the most prevalent internal posttranscriptional modification on mammalian mRNA.
Journal ArticleDOI
Diabetes increases mortality after myocardial infarction by oxidizing CaMKII.
Min Luo,Xiaoqun Guan,Elizabeth D. Luczak,Di Lang,William Kutschke,Zhan Gao,Jinying Yang,Patric Glynn,Samuel Sossalla,Paari Dominic Swaminathan,Robert M. Weiss,Baoli Yang,Adam G. Rokita,Adam G. Rokita,Lars S. Maier,Igor R. Efimov,Thomas J. Hund,Mark E. Anderson +17 more
TL;DR: The findings suggest that activation of a mitochondrial/ox-CaMKII pathway contributes to increased sudden death in diabetic patients after myocardial infarction.